Frank Robert N
Wayne State University School of Medicine, The Kresge Eye Institute, 4717 Saint Antoine, Detroit, MI 48201, USA.
Curr Opin Investig Drugs. 2009 Apr;10(4):327-35.
The hypothesis that soluble vasoproliferative growth factors cause new blood vessel growth (neovascularization) in proliferative diabetic retinopathy and other proliferative diseases of the retina was first proposed by Isaac Michaelson in 1948. Until recently, laser photocoagulation has been the preferred treatment for these diseases. VEGF, first identified in 1983 and associated with diabetic retinopathy in 1994, has been the focus of increasing research in this field. Several types of anti-VEGF molecules are being evaluated for efficacy; however, it is becoming evident that VEGF may not be the only, or even the major, molecule responsible for diabetic macular edema.
可溶性血管增殖生长因子在增殖性糖尿病视网膜病变及其他视网膜增殖性疾病中导致新血管生长（新生血管形成）这一假说最早由艾萨克·迈克尔森于1948年提出。直到最近，激光光凝术一直是这些疾病的首选治疗方法。血管内皮生长因子（VEGF）于1983年首次被发现，并于1994年被证实与糖尿病视网膜病变有关，一直是该领域越来越多研究的焦点。几种抗VEGF分子正在接受疗效评估；然而，越来越明显的是，VEGF可能不是导致糖尿病性黄斑水肿的唯一分子，甚至不是主要分子。
