Masssachusetts General Hospital/Massachusetts Institute of Technology/Harvard Medical School Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA.
Hippocampus. 2010 Jan;20(1):166-73. doi: 10.1002/hipo.20597.
Current source densities in different layers of the human entorhinal cortex (ER) were recorded using a linear array of 24 microelectrodes during three memory conditions: a remote autobiographical condition eliciting recollections of events that occurred 10 or more years ago in the participant's past, a semantic icon condition invoking the mental image of a well-known object, and a semantic knowledge condition asking about general information. Our data demonstrate theta, gamma, and delta oscillations in left ER particularly for remote autobiographical memory. Gamma is predominant in hippocampally projecting layers during presentation of the memory cue, whereas theta is prolonged and dominant in cortically projecting layers during memory retrieval. Gamma interactions between ER and hippocampal formation (HF) may elicit an HF contribution to recall under influences relayed from the association cortex (AC). This contribution may then be relayed back to AC during retrieval of the memory orchestrated by theta interactions with ER. Accordingly, theta oscillations were recorded simultaneously in frontal and temporal cortices.
使用线性排列的 24 个微电极，在三种记忆条件下记录人类内嗅皮层 (ER) 不同层的源密度：一个远程自传体条件，唤起参与者过去 10 年或更早发生的事件的回忆；一个语义图标的条件，唤起一个知名物体的心理图像；一个语义知识条件，询问一般信息。我们的数据表明，左 ER 中的θ波、γ波和δ波在远程自传体记忆中尤其明显。在呈现记忆提示时，海马投射层中γ波占主导地位，而在记忆检索时，θ波延长并占主导地位。ER 与海马结构 (HF) 之间的γ波相互作用可能会在来自联合皮层 (AC) 的传递影响下引起 HF 对回忆的贡献。这种贡献可能会在由 ER 与θ波相互作用协调的记忆检索过程中，被反馈回 AC。因此，θ波振荡同时在额叶和颞叶皮层中被记录下来。
