Knake Susanne, Wang Chun Mao, Ulbert Istvan, Schomer Donald L, Halgren Eric
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Neuroimage. 2007 Aug 15;37(2):618-22. doi: 10.1016/j.neuroimage.2007.05.009. Epub 2007 May 18.
Population transmembrane currents and neuronal firing in different layers of the human entorhinal cortex (ER) were recorded during semantic and episodic memory processes using a linear array of 24 laminar microelectrodes. Both measures, as well as local broadband spectral power, increased during retrieval of newly-learned characteristics, especially in superficial layers. No differences were observed in the activity evoked by remembering people as compared to places. Semantic retrieval evoked similar activity. In contrast, intentional encoding of declarative memory evoked relatively little activity. A double-dissociation of these responses with simultaneously recorded lateral inferotemporal recordings suggests that entorhinal cortex may be specifically engaged during retrieval, across multiple memory types and materials.
使用24个层流微电极的线性阵列，在语义和情景记忆过程中记录了人类内嗅皮层（ER）不同层的群体跨膜电流和神经元放电。在检索新学习的特征时，这两种测量方法以及局部宽带频谱功率均增加，尤其是在表层。与地点相比，在回忆人物时诱发的活动没有差异。语义检索诱发了类似的活动。相比之下，陈述性记忆的有意编码诱发的活动相对较少。这些反应与同时记录的颞下回外侧记录的双重分离表明，内嗅皮层可能在多种记忆类型和材料的检索过程中特别活跃。
