Atkin N B, Fox M F
Department of Cancer Research, Mount Vernon Hospital, Northwood, Middlesex, England.
Cancer Genet Cytogenet. 1991 Sep;55(2):153-6. doi: 10.1016/0165-4608(91)90071-2.
The findings on direct chromosome preparations of a moderately differentiated squamous cell carcinoma of the vagina are described. Most counts were in the range 82-86. Eight markers were present in at least five of six metaphases karyotyped: 3p- (1-2 copies); i(5p) or possibly 5q- (2-3 copies); i(8q) (2 copies); 11q- (2-4 copies); 15p+ (1-2 copies), a probable 18q- (1 copy), 22p+ (1 copy), and minute acrocentric (2-4 copies). Numerical changes included extra copies of chromosomes 7 and 13, but only one copy of chromosome 11 was present.
本文描述了对一例阴道中分化鳞状细胞癌进行直接染色体制备后的研究结果。多数计数结果在82 - 86范围内。在六个核型分析的中期相中，至少五个相中存在八个标记：3p-（1 - 2个拷贝）；i(5p)或可能是5q-（2 - 3个拷贝）；i(8q)（2个拷贝）；11q-（2 - 4个拷贝）；15p+（1 - 2个拷贝），一个可能的18q-（1个拷贝），22p+（1个拷贝），以及微小近端着丝粒染色体（2 - 4个拷贝）。数量变化包括7号和13号染色体的额外拷贝，但仅存在一个11号染色体拷贝。
