Zhuo Xianlu, Cai Lei, Xiang Zhaolan, Li Qi, Zhang Xueyuan
Department of Otolaryngology, Southwest Hospital, Third Military Medical University, Chongqing, PR China.
J Exp Clin Cancer Res. 2009 Apr 1;28(1):46. doi: 10.1186/1756-9966-28-46.
Previous evidence implicates polymorphisms of GSTM1 and GSTT1, candidates of phase II enzymes, as risk factors for various cancers. A number of studies have conducted on the association of GSTM1 and GSTT1 polymorphism with susceptibility to nasopharyngeal carcinoma (NPC). However, inconsistent and inconclusive results have been obtained. In the present study, we aimed to assess the possible associations of NPC risk with GSTM1 and GSTM1 null genotype, respectively.
The associated literature was acquired through deliberate searching and selected based on the established inclusion criteria for publications, then the extracted data were further analyzed using systematic meta-analyses.
A total of 85 articles were identified, of which eight case-control studies concerning NPC were selected. The results showed that the overall OR was 1.42 (95%CI = 1.21-1.66) for GSTM1 polymorphism. While for GSTT1 polymorphism, the overall OR was 1.12 (95% CI = 0.93-1.34).
The data were proven stable via sensitivity analyses. The results suggest GSTM1 deletion as a risk factor for NPC and failed to suggest a marked correlation of GSTT1 polymorphisms with NPC risk.
先前的证据表明，II期酶的候选基因谷胱甘肽S-转移酶M1（GSTM1）和谷胱甘肽S-转移酶T1（GSTT1）的多态性是多种癌症的危险因素。许多研究已经探讨了GSTM1和GSTT1基因多态性与鼻咽癌（NPC）易感性之间的关联。然而，研究结果并不一致且尚无定论。在本研究中，我们旨在分别评估NPC风险与GSTM1和GSTM1缺失基因型之间的可能关联。
通过精心检索获取相关文献，并根据既定的纳入标准进行筛选，然后使用系统的荟萃分析对提取的数据进行进一步分析。
共检索到85篇文章，其中选取了8项关于NPC的病例对照研究。结果显示，GSTM1基因多态性的总体比值比（OR）为1.42（95%置信区间[CI]=1.21-1.66）。而对于GSTT1基因多态性，总体OR为1.12（95%CI=0.93-1.34）。
通过敏感性分析验证了数据的稳定性。结果表明GSTM1缺失是NPC的一个危险因素，且未显示GSTT1基因多态性与NPC风险有明显相关性。
