Zhuo Wenlei, Wang Yan, Zhuo Xianlu, Zhu Yi, Wang Weidong, Zhu Bo, Li Dezhi, Chen Zhengtang
Institute of Cancer, Chongqing, China.
Cancer Invest. 2009 Jan;27(1):86-95. doi: 10.1080/07357900802146170.
Previous studies have implicated CYP1A1 and GSTM1 polymorphisms as risk factors for various cancers. A number of studies have been devoted to the association of CYP1A1 or GSTM1 polymorphism with susceptibility to oral carcinoma and have yielded conflicting results. The aim of the present study was to assess the possible associations of oral cancer risk with CYP1A1 genetic variation and GSTM1 null genotype respectively via systematic meta-analyses. The data suggest that variant genotypes of CYP1A1 might not be risk factors for oral cancer, whereas GSTM1 null genotype significantly increases susceptibility to oral cancer in Asians but not Caucasians.
以往的研究表明，CYP1A1和GSTM1基因多态性是多种癌症的风险因素。许多研究致力于探讨CYP1A1或GSTM1基因多态性与口腔癌易感性之间的关联，但结果相互矛盾。本研究的目的是通过系统的荟萃分析分别评估CYP1A1基因变异和GSTM1基因缺失型与口腔癌风险之间的可能关联。数据表明，CYP1A1的变异基因型可能不是口腔癌的风险因素，而GSTM1基因缺失型在亚洲人中显著增加口腔癌易感性，但在白种人中并非如此。
