谷胱甘肽S-转移酶M1和谷胱甘肽S-转移酶T1基因多态性与鼻咽癌风险的Meta分析。
Meta-analysis of GSTM1 and GSTT1 polymorphisms and risk of nasopharyngeal cancer.
作者信息
Murthy Archana Krishna, Kumar Vinod, Suresh K P
机构信息
Department of Public Health Dentistry, MR Ambedkar Dental College, Bangalore, India.
出版信息
Asian Pac J Cancer Prev. 2013;14(3):1697-701. doi: 10.7314/apjcp.2013.14.3.1697.
BACKGROUND
Studies of associations between genetic polymorphism of glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) with risk of nasopharyngeal cancer (NPC) have generated conflicting results. Thus, a meta-analysis was performed to clarify the effects of GSTM1 and GSTT1 polymorphisms on the risk of developing NPC.
MATERIALS AND METHODS
A literature search in two electronic databases namely PubMed and EMBASE up to December 2012 was conducted and eligible papers were finally selected based on the inclusion and exclusion criteria. The pooled odds ratio (OR) and presence of heterogeneity and publication bias in those studies were evaluated.
RESULTS
A total of 9 studies concerning nasopharyngeal cancer were evaluated. Analyses of all relevant studies showed increased NPC risk to be significantly associated with the null genotypes of GSTMI (OR=1.43, 95%CI 1.24-1.66) and GSTT1 (OR=1.28, 95%CI=1.09-1.51). In addition, evidence of publication bias was detected among the studies on GSTM1 polymorphism.
CONCLUSIONS
This meta-analysis demonstrated the GSTM1 and GSTT1 null genotypes are associated with an increased risk of NPC.
背景
谷胱甘肽S-转移酶M1（GSTM1）和谷胱甘肽S-转移酶T1（GSTT1）基因多态性与鼻咽癌（NPC）风险之间关联的研究结果相互矛盾。因此，进行了一项荟萃分析以阐明GSTM1和GSTT1基因多态性对患鼻咽癌风险的影响。
材料与方法
检索了截至2012年12月的两个电子数据库即PubMed和EMBASE，并根据纳入和排除标准最终筛选出符合条件的论文。评估了这些研究中的合并比值比（OR）以及异质性和发表偏倚的情况。
结果
共评估了9项关于鼻咽癌的研究。对所有相关研究的分析表明，鼻咽癌风险增加与GSTMI无效基因型（OR = 1.43，95%CI 1.24 - 1.66）和GSTT1无效基因型（OR = 1.28，95%CI = 1.09 - 1.51）显著相关。此外，在关于GSTM1基因多态性的研究中检测到了发表偏倚的证据。
结论
这项荟萃分析表明，GSTM1和GSTT1无效基因型与鼻咽癌风险增加相关。
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