Flourakis Matthieu, Prevarskaya Natacha
Inserm, U-800, Equipe labellisée par la Ligue Nationale contre le cancer, Villeneuve d'Ascq, F-59655, France.
Biochim Biophys Acta. 2009 Jun;1793(6):1105-9. doi: 10.1016/j.bbamcr.2009.01.009. Epub 2009 Jan 24.
Prostate cancer is the second cancer-related cause of death. Nowadays, the aim of treatments is to decrease the effects of androgens on this organ. Unfortunately, over time, patients develop an androgen-independent cancer with a fatal outcome. The main features of late stage prostate cancer are an increased cell proliferation and apoptosis resistance. It is well known that calcium (Ca2+), a ubiquitous secondary messenger, is involved in several processes such as apoptosis and proliferation. In this mini review, we will focus on the changes in Ca2+ homeostasis of prostate cancer epithelial cells during prostate cancer evolution.
前列腺癌是癌症相关的第二大致死原因。如今，治疗的目标是降低雄激素对该器官的影响。不幸的是，随着时间的推移，患者会发展出一种雄激素非依赖性癌症，其结局是致命的。晚期前列腺癌的主要特征是细胞增殖增加和抗凋亡。众所周知，钙（Ca2+）作为一种普遍存在的第二信使，参与了诸如凋亡和增殖等多个过程。在这篇小型综述中，我们将聚焦于前列腺癌进展过程中前列腺癌上皮细胞钙稳态的变化。
