Martinowich Keri, Schloesser Robert J, Manji Husseini K
Johnson & Johnson Pharmaceutical Research and Development, 1125 Trenton-Harbourton Road, E32000, Titusville, New Jersey 08560, USA.
J Clin Invest. 2009 Apr;119(4):726-36. doi: 10.1172/JCI37703.
Bipolar disorder (BPD) is a devastating illness that is characterized by recurrent episodes of mania and depression. In addition to these cyclic episodes, individuals with BPD exhibit changes in psychovegetative function, cognitive performance, and general health and well being. In this article we draw from neuroimaging findings in humans, postmortem data, and human genetic and pharmacological studies as well as data from animal models of behavior to discuss the neurobiology of BPD. We conclude with a synthesis of where the field stands and with suggestions and strategies for future areas of study to further increase our conceptual understanding of this complex illness.
双相情感障碍（BPD）是一种具有破坏性的疾病，其特征为躁狂和抑郁的反复发作。除了这些周期性发作外，双相情感障碍患者在精神植物神经功能、认知表现以及总体健康和幸福感方面也会出现变化。在本文中，我们借鉴了人类神经影像学研究结果、尸检数据、人类遗传学和药理学研究以及行为动物模型的数据，来探讨双相情感障碍的神经生物学。我们最后综合阐述了该领域的现状，并提出了未来研究领域的建议和策略，以进一步加深我们对这种复杂疾病的概念理解。
