Dianliang Zhang
Department of General Surgery, Associated Hospital of Qingdao University Medical College, Shandong Province, P.R. China.
Curr Opin Clin Nutr Metab Care. 2009 May;12(3):227-31. doi: 10.1097/MCO.0b013e328329d14b.
Cancer anorexia-cachexia refers to a debilitating state of cancer patients, the pathogenesis of which is still fully unknown. The article reviews recent research into the role of inflammatory mediators and cytokine gene polymorphisms in the pathogenesis of cancer cachexia.
Using transgenic mice, recent studies demonstrate that inflammatory mediators play an important role in the cancer cachexia development. Preliminary association studies in unrelated individuals exhibit that cytokine gene polymorphisms are related to cancer cachexia susceptibility.
Although its pathogenesis is not fully known, inflammatory mediators have been involved in cancer cachexia. Single-nucleotide polymorphisms in genes coding inflammatory cytokines are likely to have played some role in cancer susceptibility. It is of great essentiality to further probe cancer cachexia-anorexia.
癌症恶病质是指癌症患者出现的一种使人衰弱的状态，其发病机制仍完全不明。本文综述了炎症介质和细胞因子基因多态性在癌症恶病质发病机制中的作用的最新研究。
近期利用转基因小鼠进行的研究表明，炎症介质在癌症恶病质的发展中起重要作用。在无关个体中进行的初步关联研究显示，细胞因子基因多态性与癌症恶病质易感性有关。
尽管其发病机制尚未完全明确，但炎症介质已被证实与癌症恶病质有关。编码炎症细胞因子的基因中的单核苷酸多态性可能在癌症易感性中发挥了一定作用。进一步探究癌症恶病质-厌食症至关重要。
