Demas Kristina L, Costenbader Karen H
Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Curr Opin Rheumatol. 2009 Mar;21(2):102-9. doi: 10.1097/BOR.0b013e328323daad.
Systemic lupus erythematosus (SLE), an inflammatory rheumatic disease characterized by autoantibody production and diverse clinical manifestations, disproportionately affects vulnerable groups: women, racial and ethnic minorities, the poor and those lacking medical insurance and education. We summarize the current knowledge of the disparities observed in SLE and highlight recent research that aims to dissect the causes of these disparities and identify the potentially modifiable factors contributing to them.
Several remediable causes, including lack of education, self-efficacy and access to quality, experienced healthcare have been found to contribute to observed disparities in SLE prevalence and outcomes.
SLE is associated with alarming disparities in incidence, severity and outcomes. The causes of these disparities are under study by several research groups. Identifying potentially correctable contributory factors should allow the development of effective strategies to improve the healthcare delivery and outcomes in all SLE patients.
系统性红斑狼疮(SLE)是一种炎症性风湿性疾病,其特征为自身抗体产生和多样的临床表现,对弱势群体的影响尤为严重,这些群体包括女性、种族和少数民族、贫困人口以及缺乏医疗保险和教育的人群。我们总结了目前关于SLE中观察到的差异的知识,并强调了最近旨在剖析这些差异的原因并确定导致这些差异的潜在可改变因素的研究。
已发现一些可补救的原因,包括缺乏教育、自我效能感以及获得高质量的、有经验的医疗保健服务,这些因素导致了SLE患病率和预后方面观察到的差异。
SLE在发病率、严重程度和预后方面存在令人担忧的差异。几个研究小组正在研究这些差异的原因。确定潜在的可纠正促成因素应有助于制定有效的策略,以改善所有SLE患者的医疗服务和预后。