Chang Chia-Ling, Chiu Cheng-Ming, Hung Su-Ying, Lee Si-Huei, Lee Chang-Shun, Huang Chi-Ming, Chou Chen-Liang
Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, 5F., No. 201, Sec. 2, Shihpai Rd., Beitou District, Taipei, 112, Taiwan, Republic of China.
Clin Rheumatol. 2009 Jun;28(6):685-91. doi: 10.1007/s10067-009-1132-0. Epub 2009 Apr 2.
Aerobic fitness is among the various aspects of rheumatoid arthritis (RA) patients' lives that may deteriorate as a result of the disease and, in doing so, influence patient attitudes toward their own general health. This cross-sectional study examined (1) relationships between patients' aerobic fitness and general health perceptions, (2) relationships between functional aerobic impairment and general health perceptions, (3) the impact of body mass index (BMI) on RA patients' cardiopulmonary functioning. Sixty-six RA patients (ten male and 56 female adults) participated in this study. Following maximum graded exercise tolerance testing to determine their subsequent aerobic fitness, they completed a version of the World Health Organization Quality of Life brief form (WHOQOL-BREF, short form) questionnaire. The one sample t test determined differences between the RA group and the reference data. We used Spearman's correlation analyses to assess the associations between variables of the WHOQOL-BREF questionnaire and patients' aerobic fitness. VO(2 peak) was on average 92.00% +/- 13.37% and 77.93% +/- 20.24% of that predicted for age-matched men and women, respectively. The female patients' BMI was significantly lower than that of the reference data (P < 0.0001). Spearman's correlation coefficient demonstrated a significant association between WHOQOL-BREF scores and VO(2 peak) in the physical (P = 0.002; mobility, work) and psychological (P = 0.009; self-esteem, body image, and negative feelings) domains for the female patients. It also demonstrated a significant association between the WHOQOL-BREF scores and functional aerobic impairment in the physical (P = 0.006; energy, mobility, activity), psychological (P = 0.008; self-esteem and body images), and environment (P = 0.035; finance, service) domains for the female patients. Our results indicated that impaired aerobic fitness, combined with poor physical and psychological well-being, influenced midlife transition in Taiwanese RA women.
有氧适能是类风湿关节炎（RA）患者生活中可能因疾病而恶化的诸多方面之一，并且这样做会影响患者对自身总体健康的态度。这项横断面研究调查了：（1）患者的有氧适能与总体健康认知之间的关系；（2）功能性有氧损伤与总体健康认知之间的关系；（3）体重指数（BMI）对RA患者心肺功能的影响。66名RA患者（10名男性和56名成年女性）参与了本研究。在进行最大分级运动耐力测试以确定他们随后的有氧适能之后，他们完成了一份世界卫生组织生活质量简表（WHOQOL - BREF，简表）问卷。单样本t检验确定了RA组与参考数据之间的差异。我们使用Spearman相关分析来评估WHOQOL - BREF问卷变量与患者有氧适能之间的关联。VO₂峰值平均分别为年龄匹配男性和女性预测值的92.00%±13.37%和77.93%±20.24%。女性患者的BMI显著低于参考数据（P < 0.0001）。Spearman相关系数表明，在女性患者的身体领域（P = 0.002；活动能力、工作）和心理领域（P = 0.009；自尊、身体形象和负面情绪），WHOQOL - BREF得分与VO₂峰值之间存在显著关联。它还表明，在女性患者的身体领域（P = 0.006；精力、活动能力、活动）、心理领域（P = 0.008；自尊和身体形象）和环境领域（P = 0.035；经济、服务），WHOQOL - BREF得分与功能性有氧损伤之间存在显著关联。我们的结果表明，有氧适能受损，再加上身体和心理健康状况不佳，影响了台湾RA女性的中年过渡期。
