Wang Tao, Hu Kai, Ren Jinghua, Zhu Qingyao, Wu Gang, Peng Gang
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, China.
Mol Biol Rep. 2010 Jan;37(1):59-65. doi: 10.1007/s11033-009-9526-2. Epub 2009 Apr 2.
Polymorphism of vascular endothelial growth factor (VEGF) influences the VEGF responsiveness and is implicated in various types of diseases with a putative angiogenic basis, but its role in nasopharyngeal carcinoma (NPC) is not fully understood. In this report, we sought to investigate whether the VEGF-2578C/A polymorphism was associated with NPC in a Chinese population. We carried out polymerase chain reaction-restriction fragment length polymorphism in blood genomic DNA of 156 NPC patients and 161 control subjects. The VEGF-2578A allele carriers were significantly associated with an increased risk of NPC (odds ratio: 1.648; 95% confidence interval: 1.053-2.580; P = 0.029). In contrast, NPC patients with the -2578CC genotype were shown higher tumor aggressiveness of large tumor size, poor differentiation and advanced stage as compared to the -2578A allele carriers. No correlation was observed between the genotype or allele distribution and lymph node metastasis or family history of cancer. The VEGF-2578C/A polymorphism was shown to be inconsistent with the onset and aggressiveness of NPC. The precise mechanisms of the polymorphism on the differing status in NPC should be elucidated in further studies.
血管内皮生长因子（VEGF）的多态性影响VEGF反应性，并与各种具有假定血管生成基础的疾病有关，但其在鼻咽癌（NPC）中的作用尚未完全明确。在本报告中，我们试图研究VEGF - 2578C/A多态性是否与中国人群中的鼻咽癌相关。我们对156例鼻咽癌患者和161例对照者的血液基因组DNA进行了聚合酶链反应 - 限制性片段长度多态性分析。VEGF - 2578A等位基因携带者与鼻咽癌风险增加显著相关（优势比：1.648；95%置信区间：1.053 - 2.580；P = 0.029）。相比之下，与 - 2578A等位基因携带者相比，具有 - 2578CC基因型的鼻咽癌患者表现出更大的肿瘤大小、较差的分化程度和晚期阶段等更高的肿瘤侵袭性。未观察到基因型或等位基因分布与淋巴结转移或癌症家族史之间的相关性。VEGF - 2578C/A多态性与鼻咽癌的发病和侵袭性不一致。该多态性在鼻咽癌不同状态下的确切机制应在进一步研究中阐明。
