Deepak Praveen, Kumar Sanjay, Acharya Arbind
Immunology Lab, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Cancer Invest. 2009 Jul;27(6):641-9. doi: 10.1080/07357900802622758.
Interleukin-13 (IL-13) is a T(H)2 cytokine that plays a crucial role in the pathophysiology of tumors and favor tumor growth and recurrence by negative regulation of tumor immunosurveillance. In the present investigation, we have determined the IL-13 level in the serum and ascitic fluid of the DL-bearing host and the possible source of IL-13 in the ascitic fluid. IL-13 level was elevated in serum and ascitic fluid of host bearing a transplantable T-cell lymphoma. DL cells as well as tumor-associated macrophages express and secrete IL-13 in the milieu, which provide further insight for DL-induced immunosuppression in a tumor-bearing host.
白细胞介素-13（IL-13）是一种辅助性T细胞2（TH2）细胞因子，在肿瘤的病理生理学中起关键作用，通过对肿瘤免疫监视的负调控促进肿瘤生长和复发。在本研究中，我们测定了携带弥漫性大B细胞淋巴瘤（DL）宿主的血清和腹水中IL-13水平以及腹水中IL-13的可能来源。携带可移植性T细胞淋巴瘤的宿主血清和腹水中IL-13水平升高。DL细胞以及肿瘤相关巨噬细胞在这种环境中表达并分泌IL-13，这为DL诱导荷瘤宿主免疫抑制提供了进一步的见解。
