Manilal-Reddy P I, Al-Jumaily A M
Diagnostics and Control Research Centre, Engineering Research Institute, Auckland University of Technology, Auckland, New Zealand.
J Med Eng Technol. 2009;33(3):214-22. doi: 10.1080/03091900601164838.
A continuous oscillatory positive airway pressure with pressure oscillations incidental to the mean airway pressure (bubble CPAP) is defined as a modified form of traditional continuous positive airway pressure (CPAP) delivery where pressure oscillations in addition to CPAP are administered to neonates with lung diseases. The mechanical effect of the pressure oscillations on lung performance is investigated by formulating mathematical models of a typical bubble CPAP device and a simple representation of a neonatal respiratory system. Preliminary results of the respiratory system's mechanical response suggest that bubble CPAP may improve lung performance by minimizing the respiratory system impedance and that the resonant frequency of the respiratory system may be a controlling factor. Additional steps in terms of clinical trials and a more complex respiratory system model are required to gain a deeper insight into the mechanical receptiveness of the respiratory system to pressure oscillations. However, the current results are promising in that they offer a deeper insight into the trends of variations that can be expected in future extended models as well as the model philosophies that need to be adopted to produce results that are compatible with experimental verification.
一种持续振荡式气道正压通气，其压力振荡伴随平均气道压力（气泡式持续气道正压通气），被定义为传统持续气道正压通气（CPAP）输送的一种改良形式，即在对患有肺部疾病的新生儿进行CPAP通气的同时施加压力振荡。通过构建典型气泡式CPAP装置的数学模型和新生儿呼吸系统的简单表示形式，研究压力振荡对肺部性能的机械效应。呼吸系统机械反应的初步结果表明，气泡式CPAP可能通过最小化呼吸系统阻抗来改善肺部性能，并且呼吸系统的共振频率可能是一个控制因素。需要在临床试验和更复杂的呼吸系统模型方面采取进一步措施，以更深入地了解呼吸系统对压力振荡的机械接受性。然而，目前的结果很有前景，因为它们能更深入地洞察未来扩展模型中预期的变化趋势，以及为产生与实验验证相符的结果而需要采用的模型理念。
