[采用多模式方法治疗的葡萄膜黑色素瘤患者的眼内保留情况]
[Ocular retention in patients with uveal melanoma managed by a multimodality approach].
作者信息
García-Alvarez C, Muiños Y, Saornil M A, Almaraz A, López-Lara F, Frutos J M, Muñoz M F
机构信息
Unidad de Tumores Intraoculares del Adulto, CSUR del SNS, Servicios de Radioterapia, Oftalmología y Unidad de Investigación, Hospital Clínico Universitario, Valladolid, España.
出版信息
Arch Soc Esp Oftalmol. 2009 Mar;84(3):145-9. doi: 10.4321/s0365-66912009000300007.
OBJECTIVE
to analyze ocular survival in eyes with uveal melanoma treated with conservative therapies, in a centre that applies all treatment modalities.
METHODS
Patients diagnosed with uveal melanoma and treated between September 1990 and April 2007 were included in an historical cohorts study.
RESULTS
273 patients were included. 193 were treated with conservative treatments (70.69%) and 80 were enucleated as primary treatment. 14 patients were enucleated after conservative treatment (7.2%). Kaplan-Meier survival analysis showed an 88% survival probability of the eye in the first 5 years after conservative treatment and 83% at 10 years.
CONCLUSIONS
Conservative treatments for uveal melanoma, especially brachitherapy, are safe and effective in relation to tumor control and rate of secondary effects.
目的
在一个采用所有治疗方式的中心，分析采用保守疗法治疗的葡萄膜黑色素瘤患者的眼部生存率。
方法
将1990年9月至2007年4月期间诊断为葡萄膜黑色素瘤并接受治疗的患者纳入一项历史性队列研究。
结果
共纳入273例患者。193例接受了保守治疗（70.69%），80例作为初始治疗接受了眼球摘除术。14例患者在保守治疗后接受了眼球摘除术（7.2%）。Kaplan-Meier生存分析显示，保守治疗后第1年眼部生存率为88%，第10年为83%。
结论
葡萄膜黑色素瘤的保守治疗，尤其是近距离放疗，在肿瘤控制和副作用发生率方面是安全有效的。
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