Irons G B, Hodgkinson D J, Chong G C, Woods J E
Department of Surgery, Mayo Clinic and Mayo Foundation, Rochester, MN 55901, USA.
Ann Plast Surg. 1979 Apr;2(4):286-9. doi: 10.1097/00000637-197904000-00003.
There has long been a need for a potent, nonaddicting analgesic for the treatment of certain patients who have intractable pain that cannot be controlled by the more commonly used oral analgesics. Pentazocine was introduced on the market in I967 and has been reported to be a potent analgesic, comparable to meperidine and morphine but without their addicting properties. Consequently, this drug has been used on a long-term basis, and on many occasions the injections have been given by the patient or by nonprofessionals. The result has been a few instances of misuse and overuse. We have seen 14 patients with extensive cutaneous ulcerations, subcutaneous fibrosis, and multiple fistulous tracts due to the abuse of parenterally administered pentazocine. The tissue changes have a characteristic appearance and course, and it has been our experience that conservative treatment results in a poor response. We have had the best results with aggressive excision of the involved areas and coverage of the resultant defect with split-thickness skin graft.
长期以来，一直需要一种强效、无成瘾性的镇痛药，用于治疗某些患有顽固性疼痛且无法用更常用的口服镇痛药控制的患者。喷他佐辛于1967年上市，据报道是一种强效镇痛药，与哌替啶和吗啡相当，但没有它们的成瘾特性。因此，这种药物已被长期使用，而且在很多情况下是由患者或非专业人员进行注射。结果出现了一些误用和滥用的情况。我们已经见过14例因滥用胃肠外给药的喷他佐辛而出现广泛皮肤溃疡、皮下纤维化和多处瘘管的患者。组织变化具有特征性外观和病程，根据我们的经验，保守治疗效果不佳。我们通过积极切除受累区域并用中厚皮片覆盖由此产生的缺损取得了最佳效果。
