Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, Madhya Pradesh, India.
Nanomedicine. 2009 Dec;5(4):432-42. doi: 10.1016/j.nano.2009.03.001. Epub 2009 Mar 31.
This work presents a novel cascade of chemical functionalization of multiwalled carbon nanotubes (MWCNTs) through chemical modification by a carbohydrate, D-galactose. Galactose-conjugated or galactosylated MWCNTs were synthesized involving the sequential steps of carboxylation, acylation, amine modification, and finally, galactose conjugation. The modification of MWCNTs with galactose was investigated by elemental analysis, x-ray diffraction analysis, Fourier transform-infrared spectroscopy, Raman spectroscopy, and zeta potential measurements, at every sequential step of functionalization. Size and surface characteristics of chemically modified MWCNTs were monitored by transmission electron microscopy and scanning electron microscopy. That galactosylation improved the dispersibility of MWCNTs in aqueous solvents was confirmed by investigation of their dispersion characteristics at different pH values. Thus, the galactosylated MWCNTs as developed could be used for delivery of different bioactive(s) as well as active ligand (galactose)-based targeting to hepatic tissue.
This work presents a novel cascade of functionalization of multiwalled carbon nanotubes (MWCNTs) through chemical modification by a carbohydrate. Galactosylation improves the dispersibility of MWCNTs in aqueous solvents. The galactosylated MWCNTs could be used for delivery of different bioactive(s) as well as active ligand-based targeting to hepatic tissue.
这项工作提出了一种通过碳水化合物（D-半乳糖）化学修饰对多壁碳纳米管（MWCNTs）进行新型级联化学功能化的方法。通过羧基化、酰化、胺修饰，最后进行半乳糖缀合，合成了半乳糖缀合或半乳糖化的 MWCNTs。通过元素分析、X 射线衍射分析、傅里叶变换红外光谱、拉曼光谱和 Zeta 电位测量，在功能化的每一步都研究了 MWCNTs 的修饰情况。通过透射电子显微镜和扫描电子显微镜监测了化学修饰 MWCNTs 的尺寸和表面特性。通过研究不同 pH 值下的分散特性，证实了半乳糖化提高了 MWCNTs 在水溶剂中的分散性。因此，开发的半乳糖化 MWCNTs 可用于输送不同的生物活性物质以及基于活性配体（半乳糖）的肝组织靶向。
这项工作提出了一种通过碳水化合物化学修饰对多壁碳纳米管（MWCNTs）进行新型级联功能化的方法。半乳糖化提高了 MWCNTs 在水溶剂中的分散性。半乳糖化 MWCNTs 可用于输送不同的生物活性物质以及基于活性配体（半乳糖）的肝组织靶向。
