Westhoff Carolyn, Jones Kandice, Robilotto Christina, Heartwell Stephen, Edwards Sharon, Zieman Mimi, Cushman Linda
Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Contraception. 2009 May;79(5):375-8. doi: 10.1016/j.contraception.2008.12.003.
Smoking may be related to early discontinuation of oral contraceptives (OC).
This was a planned secondary analysis of a randomized clinical trial. Women aged less than 25 initiating OC at three inner-city publicly funded family planning clinics enrolled in the study. Subjects reported smoking status at enrollment; 3- and 6-month interviews assessed OC continuation.
One hundred eighty-nine (12%) of 1598 participants were current smokers. Smokers were more often lost to follow-up than nonsmokers (P<.01). Among participants with a 6-month interview, only 26% of smokers and 46% of nonsmokers were continuing OC (P<.001). After adjustment for confounding factors, smokers were still somewhat less likely to be continuing OC (adjusted OR 0.6, 95% CI 0.4-1.0). This association was unrelated to number of cigarettes smoked per day.
These data suggest that young smokers may be more likely to discontinue OC within 6 months than nonsmokers. Smoking may be a marker for risk-taking behavior that extends to the premature discontinuation of OC.
吸烟可能与口服避孕药（OC）的早期停用有关。
这是一项对随机临床试验的计划二次分析。年龄小于25岁、在三家市中心由公共资金资助的计划生育诊所开始服用OC的女性参与了该研究。受试者在入组时报告吸烟状况；3个月和6个月的访谈评估OC的持续使用情况。
1598名参与者中有189名（12%）为当前吸烟者。吸烟者比非吸烟者更常失访（P<.01）。在接受6个月访谈的参与者中，只有26%的吸烟者和46%的非吸烟者仍在继续服用OC（P<.001）。在对混杂因素进行调整后，吸烟者继续服用OC的可能性仍然略低（调整后的比值比为0.6，95%可信区间为0.4 - 1.0）。这种关联与每日吸烟量无关。
这些数据表明，年轻吸烟者在6个月内停用OC的可能性可能比非吸烟者更高。吸烟可能是冒险行为的一个标志，这种行为延伸到过早停用OC。
