Department of Obstetrics and Gynecology, The Hebrew University Medical School, Hadassah Ein-Kerem, POB 12000 Jerusalem 91120, Israel.
Fertil Steril. 2010 Feb;93(2):351-4. doi: 10.1016/j.fertnstert.2009.02.027. Epub 2009 Apr 1.
To assess whether supplementation with hCG throughout the secretory phase of hormonally modulated cycles of frozen-thawed embryos might positively affect the outcome of such cycles.
Prospective, randomized controlled trial.
University teaching hospital.
PATIENT(S): Patients undergoing frozen-thawed embryo transfer cycles.
INTERVENTION(S): Patients were randomly divided into two groups by the last digit of their identification number. Group A received our standard protocol for endometrial preparation, whereas group B patients were given an additional 250 microg of recombinant hCG on day of P initiation, the day of embryo transfer, and 6 days later. Throughout the cycle, and to compare between the groups, serial ultrasound examinations and hormonal tests of E(2) and P serum levels were obtained.
MAIN OUTCOME MEASURE(S): Implantation and clinical pregnancy rates (PR).
RESULT(S): One hundred sixty-five patients were enrolled in this study, 78 in the control group and 87 in the hCG-treated group. Progesterone levels and endometrial thickness were similar throughout the cycle in both groups. The E(2) level was significantly higher in group B on the day of embryo transfer and 6 days later. The PRs did not differ between the two groups (28.2% and 32.2% for groups A and B, respectively). Similarly, the implantation rates were comparable between the groups (12.7% and 14.9%, respectively).
CONCLUSION(S): No advantage was found concerning PR and implantation rate by supplementing the secretory phase with hCG in patients undergoing transfer of frozen-thawed embryo in hormonally modulated cycles.
评估在冻融胚胎激素调节周期的分泌期全程补充 hCG 是否会对该周期的结局产生积极影响。
前瞻性、随机对照试验。
大学教学医院。
接受冻融胚胎移植周期的患者。
通过患者识别号的最后一位数字将患者随机分为两组。A 组接受我们的标准子宫内膜准备方案，而 B 组患者在 P 启动日、胚胎移植日和 6 天后额外给予 250μg 重组 hCG。在整个周期中，为了在组间进行比较，对患者进行了系列超声检查和血清 E（2）和 P 水平的激素检测。
种植率和临床妊娠率（PR）。
本研究共纳入 165 例患者，对照组 78 例，hCG 治疗组 87 例。两组患者整个周期的孕激素水平和子宫内膜厚度相似。B 组患者在胚胎移植日和 6 天后的 E（2）水平显著升高。两组间 PR 无差异（A 组和 B 组分别为 28.2%和 32.2%）。同样，两组的种植率也相当（分别为 12.7%和 14.9%）。
在接受激素调节冻融胚胎移植的患者中，在分泌期补充 hCG 并未发现对 PR 和种植率有优势。
