Department of Obstetrics and Gynecology, In Vitro Fertilization Unit, Ein Kerem, Hebrew University, Hadassah Medical Center, POB 12000, Jerusalem, 91120, Israel.
J Assist Reprod Genet. 2012 Nov;29(11):1227-39. doi: 10.1007/s10815-012-9861-4. Epub 2012 Sep 14.
Repeated implantation failure (RIF) is determined when embryos of good quality fail to implant following several in vitro fertilization (IVF) treatment cycles. Implantation failure is related to either maternal factors or embryonic causes. Maternal factors include uterine anatomic abnormalities, thrombophilia, non-receptive endometrium and immunological factors. Failure of implantation due to embryonic causes is associated with either genetic abnormalities or other factors intrinsic to the embryo that impair its ability to develop in utero, to hatch and to implant. New methods of time-lapse imaging of embryos and assessment of their metabolic functions may improve selection of embryos for transfer, and subsequent outcomes for IVF patients, as well as for those diagnosed with RIF. This review discusses the various causes associated with RIF and addresses appropriate treatments.
反复着床失败（RIF）是指在多次体外受精（IVF）治疗周期后，优质胚胎未能着床。着床失败与母体因素或胚胎原因有关。母体因素包括子宫解剖结构异常、血栓形成倾向、容受性子宫内膜和免疫因素。胚胎原因导致的着床失败与遗传异常或胚胎内在的其他因素有关，这些因素会损害胚胎在子宫内发育、孵化和着床的能力。胚胎延时成像新技术和代谢功能评估可能会改善胚胎的选择，从而提高 IVF 患者和 RIF 患者的后续妊娠结局。本文讨论了与 RIF 相关的各种原因，并探讨了相应的治疗方法。
