肥胖的心血管后果及治疗靶点
Cardiovascular Consequences of Obesity and Targets for Treatment.
作者信息
Mittendorfer Bettina, Peterson Linda R
机构信息
Department of Medicine, divisions of geriatrics and nutritional sciences, Washington University School of Medicine, St. Louis, MO, USA.
出版信息
Drug Discov Today Ther Strateg. 2008;5(1):53-61. doi: 10.1016/j.ddstr.2008.07.001.
Abstract
Obesity is a risk factor for cardiovascular disease, including coronary artery disease and heart failure, but the mechanisms by which it may cause them are not completely clear. Currently, therapies aimed at obesity-related cardiovascular disease include weight loss strategies and reduction of the other risk factors that are associated with obesity and cardiovascular disease. Other pathways with for potential drug development for obesity-related CVD are also discussed.
摘要
肥胖是心血管疾病的一个风险因素，包括冠状动脉疾病和心力衰竭，但其可能导致这些疾病的机制尚不完全清楚。目前，针对肥胖相关心血管疾病的治疗方法包括减肥策略以及降低与肥胖和心血管疾病相关的其他风险因素。文中还讨论了肥胖相关心血管疾病潜在药物研发的其他途径。
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本文引用的文献
1
Heart disease and stroke statistics--2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.
Circulation. 2008 Jan 29;117(4):e25-146. doi: 10.1161/CIRCULATIONAHA.107.187998. Epub 2007 Dec 17.
2
Gender-specific characteristics of atherosclerosis in menopausal women: risk factors, clinical course and strategies for prevention.
Climacteric. 2007 Oct;10 Suppl 2:16-20. doi: 10.1080/13697130701602712.
3
Association of overweight with increased risk of coronary heart disease partly independent of blood pressure and cholesterol levels: a meta-analysis of 21 cohort studies including more than 300 000 persons.
Arch Intern Med. 2007 Sep 10;167(16):1720-8. doi: 10.1001/archinte.167.16.1720.
4
Long-term mortality after gastric bypass surgery.
N Engl J Med. 2007 Aug 23;357(8):753-61. doi: 10.1056/NEJMoa066603.
5
Effects of bariatric surgery on mortality in Swedish obese subjects.
N Engl J Med. 2007 Aug 23;357(8):741-52. doi: 10.1056/NEJMoa066254.
6
Metabolic syndrome: treatment of hypertensive patients.
Am J Ther. 2007 Jul-Aug;14(4):386-402. doi: 10.1097/01.pap.0000249936.05650.0c.
7
Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women.
JAMA. 2007 Jul 18;298(3):309-16. doi: 10.1001/jama.298.3.309.
8
Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women.
JAMA. 2007 Jul 18;298(3):299-308. doi: 10.1001/jama.298.3.299.
9
Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins.
Diabetes. 2007 Oct;56(10):2457-66. doi: 10.2337/db07-0481. Epub 2007 Jul 10.
10
Selective resistance to vasoactive effects of insulin in muscle resistance arteries of obese Zucker (fa/fa) rats.
Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1134-9. doi: 10.1152/ajpendo.00516.2006. Epub 2007 Jul 10.
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