Luque Rafael, Macquarrie Duncan J
Green Chemistry Centre of Excellence, The University of York, Heslington, York, UK YO10 5DD.
Org Biomol Chem. 2009 Apr 21;7(8):1627-32. doi: 10.1039/b821134p. Epub 2009 Mar 6.
An efficient metal-free Sonogashira coupling protocol catalysed by DABCO is reported, where very good conversions and selectivities to the cross-coupling product were obtained under mild reaction conditions. The reported solvent-, phosphane- and metal-free protocol, that uses a cheap base as catalyst, considerably improves the green credentials of the reaction.
报道了一种由1,4-二氮杂双环[2.2.2]辛烷（DABCO）催化的高效无金属Sonogashira偶联反应方案，该方案在温和的反应条件下能获得对交叉偶联产物非常好的转化率和选择性。所报道的无溶剂、无膦和无金属的反应方案使用廉价碱作为催化剂，大大提高了该反应的绿色环保程度。
