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Copper-free sonogashira coupling reaction with PdCl2 in water under aerobic conditions.

作者信息

Liang Bo, Dai Mingji, Chen Jiahua, Yang Zhen

机构信息

Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Beijing 100871, China.

出版信息

J Org Chem. 2005 Jan 7;70(1):391-3. doi: 10.1021/jo048599z.

DOI:10.1021/jo048599z
PMID:15624959
Abstract

A mild protocol for the copper-free Sonogashira coupling of aryl iodides with terminal acetylenes in water under aerobic conditions has been developed. The use of 1 mol % PdCl(2) in the presence of pyrrolidine allows the coupling reaction to proceed at room temperature or 50 degrees C with good to excellent yields.

摘要

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