肢体局限性尤因肉瘤或骨肉瘤患者长期随访的健康状况：一项斯堪的纳维亚肉瘤组研究

Health status at long-term follow-up in patients treated for extremity localized Ewing Sarcoma or osteosarcoma: a Scandinavian sarcoma group study.

作者信息

Aksnes L H, Bauer H C F, Dahl A A, Fosså S D, Hjorth L, Jebsen N, Lernedal H, Hall K Sundby

机构信息

Department of Oncology, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway.

出版信息

Pediatr Blood Cancer. 2009 Jul;53(1):84-9. doi: 10.1002/pbc.22027.

DOI:10.1002/pbc.22027

PMID:19343771

Abstract

BACKGROUND

The purpose of this study was to evaluate late effects and symptom complaints in long-term survivors (>5 years) of Extremity Bone Sarcoma (EBS survivors). The results were compared with findings in age- and gender-matched individuals from the general population (NORMs).

PATIENTS AND METHODS

Among 155 EBS survivors approached, 133 (86%) were included, and 110 of them (83%) attended an outpatient examination. Health status was evaluated by a mailed questionnaire concerning demographic and current health issues, and physical examinations at the outpatient clinic. Age- and gender-adjusted normative controls were drawn from participants of the Health Study of Nord-Trøndelag County (HUNT 2).

RESULTS

Median age at follow-up was 29 (15-57) years. Median follow-up was 12 (6-22) years. Of EBS survivors 42% had > or =1 somatic disease, 33% had ototoxicity and 13% had reduced renal function. EBS survivors were more likely to have heart disease (odds ratio [OR], 7.9; 95% confidence interval [95% CI], 2.5-25.3; P = 0.001), hypertension (OR, 3.4; 95% CI, 1.1-10.1; P = 0.03) and thyroid disease (OR, 3.0; 95% CI, 1.1-8.3; P = 0.04) compared to NORMs. EBS survivors reported more diarrhoea (29% vs. 19%, P = 0.02), palpitations (23% vs. 13%, P = 0.01) and shortness of breath (11% vs. 5%, P = 0.01) than NORMs.

CONCLUSIONS

EBS survivors have poorer health status compared to age- and gender-matched controls. Long-term follow-up of these patients is therefore mandatory.

摘要

背景

本研究旨在评估肢体骨肉瘤长期幸存者（超过5年）的晚期效应和症状主诉。将结果与来自普通人群的年龄和性别匹配个体（正常对照）的研究结果进行比较。

患者与方法

在联系的155名肢体骨肉瘤幸存者中，133名（86%）被纳入研究，其中110名（83%）参加了门诊检查。通过邮寄关于人口统计学和当前健康问题的问卷以及在门诊进行体格检查来评估健康状况。年龄和性别调整后的正常对照来自北特伦德拉格郡健康研究（HUNT 2）的参与者。

结果

随访时的中位年龄为29岁（15 - 57岁）。中位随访时间为12年（6 - 22年）。肢体骨肉瘤幸存者中，42%患有≥1种躯体疾病，33%有耳毒性，13%肾功能减退。与正常对照相比，肢体骨肉瘤幸存者患心脏病的可能性更高（比值比[OR]，7.9；95%置信区间[95%CI]，2.5 - 25.3；P = 0.001）、高血压（OR，3.4；95%CI，1.1 - 10.1；P = 0.03）和甲状腺疾病（OR，3.0；95%CI，1.1 - 8.3；P = 0.04）。肢体骨肉瘤幸存者报告的腹泻（29%对19%，P = 0.02）、心悸（23%对13%，P = 0.01）和呼吸急促（11%对5%，P = 0.01）比正常对照更多。