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与海洛因使用者相比,处方类阿片类药物主要使用者在美沙酮维持药物治疗中的留存情况。

Retention in methadone maintenance drug treatment for prescription-type opioid primary users compared to heroin users.

作者信息

Banta-Green Caleb J, Maynard Charles, Koepsell Thomas D, Wells Elizabeth A, Donovan Dennis M

机构信息

Alcohol and Drug Abuse Institute, University of Washington, Seattle, WA 98105, USA.

出版信息

Addiction. 2009 May;104(5):775-83. doi: 10.1111/j.1360-0443.2009.02538.x. Epub 2009 Mar 13.

Abstract

AIMS

To assess retention in methadone maintenance treatment for prescription-type opioid primary (PTOP) users compared to heroin users.

DESIGN AND PARTICIPANTS

A retrospective cohort study was carried out to examine the association between opiate types used on 12-month retention. The study population consisted of adults admitted to one of 11 not-for-profit methadone maintenance clinics in 2004 and 2005 throughout Washington State (n = 2308). Logistic regression analyses with fixed effects for treatment agencies were conducted.

MEASUREMENTS

Opiate use type in past 30 days: any heroin use or primary prescription opioid without heroin use. Demographics, other drugs used, self-reported medical and psychiatric concerns, social, familial and legal issues, public assistance type and housing stability were documented at intake using a comprehensive biopsychosocial instrument, the Treatment and Assessment Reports Generation Tool.

FINDINGS

The odds of being retained in treatment for PTOP compared to heroin users not adjusting for other factors was 1.33 (95% confidence interval [CI], 1.03, 1.71). In the final logistic regression model the odds of retention for PTOP compared to heroin users was 1.25 (95% CI, 0.93, 1.67), indicating that there was no statistically significant difference in treatment retention by opiate type after adjusting for demographics, treatment agencies, other drug use, public assistance type, medical, psychiatric, social, legal and familial factors.

CONCLUSION

The findings of this study suggest that PTOP can be treated at methadone maintenance treatment facilities at least as effectively as heroin users in terms of treatment retention.

摘要

目的

评估与海洛因使用者相比,处方类阿片原药(PTOP)使用者在美沙酮维持治疗中的留存率。

设计与参与者

开展一项回顾性队列研究,以检验使用的阿片类型与12个月留存率之间的关联。研究人群包括2004年和2005年在华盛顿州11家非营利性美沙酮维持治疗诊所之一入院的成年人(n = 2308)。对治疗机构进行了固定效应的逻辑回归分析。

测量指标

过去30天内的阿片使用类型:任何海洛因使用情况或无海洛因使用的原发性处方阿片类药物使用情况。使用综合生物心理社会工具“治疗与评估报告生成工具”在入院时记录人口统计学信息、使用的其他药物、自我报告的医疗和精神问题、社会、家庭和法律问题、公共援助类型和住房稳定性。

研究结果

在不调整其他因素的情况下,PTOP使用者与海洛因使用者相比,继续接受治疗的几率为1.33(95%置信区间[CI],1.03,1.71)。在最终的逻辑回归模型中,PTOP使用者与海洛因使用者相比继续接受治疗的几率为1.25(95%CI,0.93,1.67),这表明在调整人口统计学、治疗机构、其他药物使用、公共援助类型、医疗、精神、社会、法律和家庭因素后,按阿片类型划分的治疗留存率没有统计学上的显著差异。

结论

本研究结果表明,就治疗留存率而言,PTOP使用者在美沙酮维持治疗机构接受治疗的效果至少与海洛因使用者一样有效。

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