五名年轻兄弟中的免疫紊乱与恶性肿瘤
Immunological disorders and malignancies in five young brothers.
作者信息
Purtilo D T, Riordan J A, Deflorio D, Yang J P, Sun P, Vawter G
出版信息
Arch Dis Child. 1977 Apr;52(4):310-3. doi: 10.1136/adc.52.4.310.
Abstract
Five brothers of from 6 to 18 years of age experienced immunological or neoplastic disorders during an 8-year interval. 2 boys succumbed to glioblastoma multiforme, another to metastatic carcinoma, and the 2 surviving brothers had a histiocytic lymphoma and idiopathic thrombocytopenia purpura, respectively. The mother of the boys was healthy, but her twin sister died in utero of birth defects. We suggest that an intrinsic cellular defect inherited from their mother rendered the boys vulnerable to oncogenesis.
摘要
6至18岁的五兄弟在8年时间里患上了免疫性或肿瘤性疾病。2名男孩死于多形性胶质母细胞瘤，另一名死于转移性癌，2名存活的兄弟分别患有组织细胞性淋巴瘤和特发性血小板减少性紫癜。这些男孩的母亲身体健康，但其双胞胎妹妹死于先天性出生缺陷。我们认为，从他们母亲那里遗传来的内在细胞缺陷使这些男孩易患肿瘤。
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