Senner Claire E, Brockdorff Neil
MRC Clinical Sciences Centre, Imperial College, Hammersmith Campus, London, UK.
Curr Opin Genet Dev. 2009 Apr;19(2):122-6. doi: 10.1016/j.gde.2009.03.003. Epub 2009 Apr 1.
The large non-coding RNA Xist is the master regulator of X inactivation. Xist is negatively regulated by its antisense transcript Tsix. This repressive antisense transcription across Xist operates at least in part through the modification of the chromatin environment of the locus. However Tsix is not sufficient to repress Xist in pluripotent cells and there is emerging evidence that transcription factors associated with pluripotency are involved in Tsix-independent repression. This review focuses on recent advances in this area and discusses the implications for our understanding of Xist gene regulation at the onset of X inactivation.
大型非编码RNA Xist是X染色体失活的主要调节因子。Xist受到其反义转录本Tsix的负调控。这种跨越Xist的抑制性反义转录至少部分是通过对该基因座染色质环境的修饰来实现的。然而，Tsix不足以在多能细胞中抑制Xist，并且越来越多的证据表明与多能性相关的转录因子参与了不依赖Tsix的抑制作用。本综述重点关注该领域的最新进展，并讨论其对我们理解X染色体失活起始时Xist基因调控的意义。
