小窝蛋白在肌肉骨骼系统的发育和疾病中的作用

Caveolins in the development and diseases of musculoskeletal system.

作者信息

Serra Massimo, Scotlandi Katia

机构信息

Department of Musculoskeletal Oncology, Oncologic Research Laboratory, Servizio Sanitario Regionale Emilia-Romagna, Istituto Ortopedici Rizzoli, IRCCS, Via di Barbiano 1/10, 40136 Bologna, Italy.

出版信息

Cancer Lett. 2009 Nov 1;284(2):113-21. doi: 10.1016/j.canlet.2009.02.016. Epub 2009 Apr 3.

DOI:10.1016/j.canlet.2009.02.016

PMID:19345480

Abstract

Caveolins, essential scaffold proteins of caveolae, have emerged as versatile molecules that can influence numerous signaling pathways and disease processes. This brief review is focused on the role of caveolins in the physiology and pathology of musculoskeletal system and will discuss the key features of caveolins as related to differentiation and diseases of bone and muscle cells.

摘要

小窝蛋白是小窝的重要支架蛋白，已成为能影响众多信号通路和疾病进程的多功能分子。这篇简短综述聚焦于小窝蛋白在肌肉骨骼系统生理和病理中的作用，并将讨论与骨和肌肉细胞分化及疾病相关的小窝蛋白的关键特性。