Department of Anatomy, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany.
J Anat. 2014 Jun;224(6):681-7. doi: 10.1111/joa.12173. Epub 2014 Mar 25.
The aim of the present study was to demonstrate the location of the different members of the caveolin (cav) family in human muscle spindles. Twenty spindles of three human muscles (vastus medialis, ischiocavernosus, bulbospongiosus) from 12 cadavers were immunohistochemically stained for cav-1, cav-2, and cav-3, and the equatorial and polar regions evaluated. All layers of the outer and inner spindle capsule and all blood vessels within the spindle stained for cav-1 and cav-2. In the muscle spindle, intrafusal muscle fibres stained selectively for cav-3, but with a patchy appearance. Caveolinopathies may therefore also include changes in muscle spindle function.
本研究旨在展示人肌梭中不同 caveolin（cav）家族成员的位置。从 12 具尸体的 3 个人体肌肉（股直肌、坐骨海绵体肌、球海绵体肌）中选择 20 个肌梭，用 cav-1、cav-2 和 cav-3 进行免疫组织化学染色，并对赤道区和两极区进行评估。外、内肌梭囊的所有层和梭内的所有血管均对 cav-1 和 cav-2 染色。在肌梭内，梭内肌纤维对 cav-3 选择性染色，但呈斑驳状。因此，caveolinopathies 也可能包括肌梭功能的变化。
