在铕（III）离子存在下，利用芬顿体系通过化学发光法测定四环素。
Chemiluminescence determination of tetracyclines using Fenton system in the presence europium(III) ions.
作者信息
Kaczmarek Malgorzata, Lis Stefan
机构信息
Department of Rare Earths, Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60 - 780 Poznań, Poland.
出版信息
Anal Chim Acta. 2009 Apr 20;639(1-2):96-100. doi: 10.1016/j.aca.2009.02.047. Epub 2009 Mar 9.
A new simple chemiluminescent method for the determination of chlortetracycline (Chlor-TC), oxytetracycline (Oxy-TC) and doxycycline (Doxy-TC) is described. This method is based on the europium(III) emission as a result of the energy transfer process from the excited product of the tetracyclines oxidation to the uncomplexed Eu(III). Under the optimum conditions, calibration graphs were obtained for 4x10(-7) to 2x10(-5) mol L(-1) of Chlor-TC; 2x10(-7) to 2x10(-5) mol L(-1) of Oxy-TC and 1x10(-7) to 3x10(-5) mol L(-1) of Doxy-TC. The method was successfully applied to the determination of these drugs in pharmaceutical and veterinary formulation and honey.
描述了一种用于测定金霉素（Chlor-TC）、土霉素（Oxy-TC）和强力霉素（Doxy-TC）的新型简单化学发光方法。该方法基于能量从四环素氧化的激发产物转移到未络合的铕（III），从而产生铕（III）发射。在最佳条件下，获得了金霉素浓度为4×10⁻⁷至2×10⁻⁵mol L⁻¹、土霉素浓度为2×10⁻⁷至2×10⁻⁵mol L⁻¹以及强力霉素浓度为1×10⁻⁷至3×10⁻⁵mol L⁻¹的校准曲线。该方法已成功应用于药物制剂、兽用制剂和蜂蜜中这些药物的测定。
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