铈(IV)-含铕(III)离子的非甾体抗炎药物反应体系的化学发光及其在药物制剂和尿液中萘普生测定中的应用。

Department of Rare Earths, Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poland.

J Fluoresc. 2011 Nov;21(6):2201-5. doi: 10.1007/s10895-011-0923-2. Epub 2011 Jul 13.

The chemiluminescence (CL) of oxidation of non-steroidal anti-inflammatory drugs (NSAIDs) by Ce(IV) ions, was recorded in the presence and absence europium(III) ions, in solution of pH ~ 4 of solution. Kinetic curves and CL emission spectra of the all studied systems were discussed. CL of measurable intensity was observed in the Ce(IV)-NP-Eu(III) reaction system only in acidic solutions. The CL spectrum rcegistered for this system shows emission bands, typical of Eu(III) ions, with maximum at λ ~ 600 nm. The chemiluminescent method, based on Eu(III) emission in reaction system of NP-Ce(IV)-Eu(III) in acid solution was therefore used for the determination of naproxen in mixture of non-steroidal anti-inflammatory drugs.

铈(IV)离子氧化非甾体抗炎药（NSAIDs）的化学发光（CL），在存在和不存在铕(III)离子的情况下，在 pH ~ 4 的溶液中进行了记录。讨论了所有研究体系的动力学曲线和 CL 发射光谱。只有在酸性溶液中，Ce(IV)-NP-Eu(III)反应体系中才能观察到可测量强度的 CL。为该体系记录的 CL 光谱显示出铕(III)离子的典型发射带，最大发射波长在 λ ~ 600nm 处。因此，基于 NP-Ce(IV)-Eu(III)在酸性溶液反应体系中铕(III)发射的化学发光法被用于测定混合物中非甾体抗炎药中的萘普生。