Leontjevas Ruslan, van Hooren Susan, Waterink Wim, Mulders Ans
Department of Psychology, Open University of the Netherlands, Heerlen, The Netherlands.
Am J Alzheimers Dis Other Demen. 2009 Aug-Sep;24(4):341-8. doi: 10.1177/1533317509333905. Epub 2009 Apr 3.
The study explored whether apathy and depressive mood symptoms (DMS) are related to cognitive and functional features of dementia in 63 nursing home (NH) residents with early-onset dementia (EOD). All EOD residents from one NH (n = 41) and a random sample from another NH were assessed for depressive symptoms (Montgomery Asberg Depression Rating Scale [MADRS]), apathy (Neuropsychiatric Inventory [NPI]), global cognitive functions (Mini-Mental State Examination [MMSE]), activities of daily living (ADL, Minimum Data Set-Resident Assessment Instrument [MDS-RAI]), and overall dementia severity (Global Deterioration Scale [GDS]). DMS were not associated with apathy and dementia severity. Regression analyses adjusted for age, gender, the type of dementia, and DMS revealed that dementia severity measures accounted, respectively, for 14% (ADL), 13% (GDS), and 9% (MMSE) of the variance in apathy. In line with previous research in older patients, the higher apathy scores were associated with more cognitive and functional problems in EOD.
该研究探讨了63名患有早发性痴呆（EOD）的养老院（NH）居民中，冷漠和抑郁情绪症状（DMS）是否与痴呆的认知和功能特征相关。对来自一家养老院的所有EOD居民（n = 41）以及另一家养老院的随机样本进行了抑郁症状（蒙哥马利-阿斯伯格抑郁评定量表[MADRS]）、冷漠（神经精神科问卷[NPI]）、整体认知功能（简易精神状态检查表[MMSE]）、日常生活活动能力（ADL，最小数据集-居民评估工具[MDS-RAI]）以及整体痴呆严重程度（总体衰退量表[GDS]）的评估。DMS与冷漠及痴呆严重程度无关。在对年龄、性别、痴呆类型和DMS进行校正的回归分析中，结果显示痴呆严重程度指标分别解释了冷漠变异的14%（ADL）、13%（GDS）和9%（MMSE）。与之前针对老年患者的研究一致，EOD患者中较高的冷漠得分与更多的认知和功能问题相关。
