Santos Hérika Danielle de Miranda, Fernandes Thatiana Almeida Pereira, Souza Camila Araújo de, Cronemberger Sebastião, Calixto Nassim
Serviço de Glaucoma do Hospital São Geraldo, Hospital das Clínicas da Universidade Federal de Minas Gerais - Belo Horizonte (MG) - Brasil.
Arq Bras Oftalmol. 2009 Jan-Feb;72(1):13-7. doi: 10.1590/s0004-27492009000100003.
To assess the efficacy of latanoprost (L) and travoprost (T) as monotherapy as well as both drugs associated with 0.5% timolol maleate twice a day regarding the daily curve of intraocular pressure (DCPo) with the measurement of intraocular pressure (IOP) at 6 am in bed.
Retrospective study analyzing the daily curve of intraocular pressure of patients treated with L or T with or without 0.5% Tim. Patients who did not correctly follow the treatment were excluded. We also excluded the patients who used the prostaglandin analog associated with any other antiglaucomatous drug different from 0.5% Tim and those who were treated with more than two antiglaucomatous drugs. Statistical analysis was made through the SPSS 11.0 program calculating mean intraocular pressure (Pm), variability (V), p value and standard deviation. Ethnic aspects or type of glaucoma were no criteria of inclusion or exclusion in this study.
Seventy-five patients (142 eyes) were included. The average age was 61.7 years. Thirty-three (44.0%) patients were male and 42 (56.0%) were female. Thirteen patients (26 eyes 18.3%) used L, 18 patients (33 eyes - 23.2%) were treated with T, 18 patients (32 eyes - 22.5%) used latanoprost and 0.5% timolol (L 0.5%Tim) and 26 patients (51 eyes - 35.9%) used travoprost and 0.5% timolol (T 0.5%Tim). Chronic simple glaucoma was the most common type (92.0%), followed by congenital glaucoma (6.7%) and glaucoma secondary to cataract surgery (1.3%). Pm was 15.2 (+/- 4.2) mmHg among those treated with L and 14.8 (+/- 3.2) mmHg among the T users. Those patients showed a V of 2.0 (+/- 1.2) and 3.2 (+/- 1.9). In the group of L 0.5%Tim and T 0.5%Tim the Pm and V were 14.9 (+/- 2.2) mmHg, 15.0 (+/- 3.2) mmHg, 2.4 (+/- 1.2) and 2.8 (+/- 1.6) respectively. No statistical significant difference was found in the Pm neither with the drugs used as monotherapy nor with them associated with 0.5% timolol maleate as well as in the V with both drugs associated with 0.5% timolol maleate. However, V showed a significant statistically difference when we considered the drugs in monotherapy, the IOP fluctuation being lower with L (t= -2.9; p=0.005).
In the daily curve of intraocular pressure performed with the measurement of intraocular pressure at 6 am in bed, L and T associated with 0.5% timolol maleate had a similar efficacy; however, in monotherapy, Pm was similar in both drugs but the V obtained with L was lower the difference being statistically significant.
评估拉坦前列素（L）和曲伏前列素（T）单药治疗以及这两种药物与0.5%马来酸噻吗洛尔每日两次联合使用时，关于清晨6点卧床时眼压（IOP）测量的眼压日曲线（DCPo）的疗效。
回顾性研究分析接受L或T治疗、联合或不联合0.5%噻吗洛尔的患者的眼压日曲线。未正确遵循治疗的患者被排除。我们还排除了使用与0.5%噻吗洛尔不同的任何其他抗青光眼药物联合的前列腺素类似物的患者以及接受两种以上抗青光眼药物治疗的患者。通过SPSS 11.0程序进行统计分析，计算平均眼压（Pm）、变异性（V）、p值和标准差。种族因素或青光眼类型在本研究中不是纳入或排除标准。
纳入75例患者（142只眼）。平均年龄为61.7岁。33例（44.0%）患者为男性，42例（56.0%）为女性。13例患者（26只眼，18.3%）使用L，18例患者（33只眼，23.2%）接受T治疗，18例患者（32只眼，22.5%）使用拉坦前列素和0.5%噻吗洛尔（L 0.5%Tim），26例患者（51只眼，35.9%）使用曲伏前列素和0.5%噻吗洛尔（T 0.5%Tim）。慢性单纯性青光眼是最常见类型（92.0%），其次是先天性青光眼（6.7%）和白内障手术后继发性青光眼（1.3%）。接受L治疗的患者Pm为15.2（±4.2）mmHg，接受T治疗的患者为14.8（±3.2）mmHg。这些患者的V分别为2.0（±1.2）和3.2（±1.9）。在L 0.5%Tim和T 0.5%Tim组中，Pm和V分别为14.9（±2.2）mmHg、15.0（±3.2）mmHg、2.4（±1.2）和2.8（±1.6）。在Pm方面，单药治疗使用的药物以及与0.5%马来酸噻吗洛尔联合使用的药物之间均未发现统计学显著差异，在与0.5%马来酸噻吗洛尔联合使用的两种药物的V方面也未发现差异。然而，当我们考虑单药治疗的药物时，V显示出统计学显著差异，L的眼压波动更低（t = -2.9；p = 0.005）。
在清晨6点卧床测量眼压的眼压日曲线中，L和T与0.5%马来酸噻吗洛尔联合使用具有相似疗效；然而，在单药治疗中，两种药物的Pm相似，但L获得的V更低，差异具有统计学显著性。
