Hierner R, Täger G, Nast-Kolb D
Plastische, Rekonstruktive, Asthetishe und Handchirurgie, Zentrum für Interdisziplinäre Rekonstruktive Chirurgie, Universitätsklinikum Essen der Universität Duisburg-Essen, Hufelandstrasse 55, Essen, Germany.
Unfallchirurg. 2009 Apr;112(4):405-16; quiz 417-8. doi: 10.1007/s00113-009-1613-2.
Vascularized pedicled bone grafts are known since the beginning of the last century. Microvascular bone grafts (free vascularized bone transfer) are known since the beginning of the seventies. In many experimental and clinical studies vascularized bone grafts were compared to their non-vascularized analogues. Because of their own non-interrupted blood supply and thus nearly normal vitality vascularized bone grafts show more rapid fracture healing, more pronounced adaptation to the new mechanical loadings (e. g. graft hypertrophy), higher survival and consolidation rate in poor or bad recipient bed conditions (infection, bad vascularization) and some neovascularization potential on the surrounding tissue. Because of those properties, it became possible to successfully treat a large segmental bone defect by only few operations. As the treatment of complicated combined soft tissue/bone defects led to high complication rate up to 40 to 60% the indications of this method were altered.
带血管蒂骨移植自上世纪初就已为人所知。微血管骨移植（游离血管化骨移植）自七十年代初就已为人所知。在许多实验和临床研究中，血管化骨移植与其非血管化类似物进行了比较。由于其自身不间断的血液供应，因此具有近乎正常的活力，血管化骨移植显示出更快的骨折愈合、对新机械负荷更明显的适应性（如移植骨肥大）、在不良或较差的受区条件（感染、血管化不良）下更高的存活率和巩固率，以及对周围组织的一些新生血管形成潜力。由于这些特性，仅通过几次手术就有可能成功治疗大段骨缺损。由于治疗复杂的软组织/骨联合缺损导致高达40%至60%的高并发症发生率，这种方法的适应症发生了改变。
