Hussein Mahmoud-Rezk A, Ali Hayder O, Abdulwahed Saad R, Argoby Yahia, Tobeigei Faisal H
Pathology department, Assir Central Hospital, KSA, Saudi Arabia.
Exp Mol Pathol. 2009 Apr;86(2):134-5. doi: 10.1016/j.yexmp.2009.01.008.
Calciphylaxis is a poorly understood syndrome of vascular calcification and skin necrosis. It affects 1-4% of the population with end stage renal disease (ESRD). Disorders implicated in the pathogenesis of calciphylaxis include chronic renal failure, hypercalcemia, hyperphosphatemia, an elevated calcium-phosphate product, and secondary hyperparathyroidism (Essary, L.R. and Wick, M.R. (2000) Cutaneous calciphylaxis. An underrecognized clinicopathologic entity. Am. J. Clin. Pathol. 113, 280-287, Beitz, J.M. (2004) Calciphylaxis:an uncommon but potentially deadly form of skin necrosis. Am. J. Nurs. 104, 36-37.). Although these abnormalities are extremely common in-patients with ESRD, calciphylaxis is relatively rare. The mortality rate of calciphylaxis is about 60-80%. The leading cause of death is sepsis from necrotic skin lesions (Hitti,W.A., Papadimitriou, J.C., Bartlett, S. and Wali, R.K. (2007) Spontaneous cutaneous ulcers in a patient with a moderate degree of chronic kidney disease: a different spectrum of calciphylaxis. Scand. J. Urol. Nephrol.1-3.). Here, we report a case of calciphylaxis in a 23-year-old female with past history of chronic renal failure, renal transplantation and intake of immunosuppressive drug. The relevant literature was discussed.
钙过敏是一种血管钙化和皮肤坏死的综合征，目前人们对其了解甚少。它影响着1%至4%的终末期肾病（ESRD）患者。与钙过敏发病机制相关的病症包括慢性肾衰竭、高钙血症、高磷血症、钙磷乘积升高以及继发性甲状旁腺功能亢进（埃斯萨里，L.R.和威克，M.R.（2000年）皮肤钙过敏。一种未被充分认识的临床病理实体。《美国临床病理学杂志》113卷，280 - 287页，贝茨，J.M.（2004年）钙过敏：一种罕见但可能致命的皮肤坏死形式。《美国护理杂志》104卷，36 - 37页）。尽管这些异常情况在ESRD患者中极为常见，但钙过敏相对少见。钙过敏的死亡率约为60% - 80%。主要死因是坏死性皮肤病变引发的败血症（希蒂，W.A.，帕帕迪米特里乌，J.C.，巴特利特，S.和瓦利，R.K.（2007年）一名中度慢性肾病患者的自发性皮肤溃疡：钙过敏的不同表现形式。《斯堪的纳维亚泌尿学与肾脏病杂志》1 - 3页）。在此，我们报告一例23岁女性的钙过敏病例，该患者有慢性肾衰竭、肾移植病史且服用免疫抑制药物。并对相关文献进行了讨论。
