Marenzi Giancarlo
Centro Cardiologico Monzino, IRCCS, Istituto di Cardiologia, Università degli Studi, Milano.
G Ital Cardiol (Rome). 2009 Feb;10(2):88-96.
Radiological procedures that utilize intravascular iodinated contrast media are being widely applied for both diagnostic and therapeutic purposes and represent one of the main causes of contrast-induced nephropathy (CIN) and hospital-acquired renal failure. Owing to the lack of any effective treatment, prevention of this iatrogenic disease, which is associated with significant in-hospital and long-term morbidity and mortality and increased costs, is the key strategy. However, prevention of CIN continues to elude clinicians and is a main concern during percutaneous coronary interventions, as patients undergoing these procedures often have multiple comorbidities. The purpose of this article is to examine the risk factors and clinical course of CIN, as well as the most recent studies dealing with its prevention and potential therapeutic interventions, especially during percutaneous coronary interventions.
利用血管内碘化造影剂的放射学检查方法正广泛应用于诊断和治疗目的，并且是导致造影剂肾病（CIN）和医院获得性肾衰竭的主要原因之一。由于缺乏有效的治疗方法，预防这种与显著的院内及长期发病率、死亡率以及费用增加相关的医源性疾病是关键策略。然而，预防CIN仍然困扰着临床医生，并且是经皮冠状动脉介入治疗期间的主要关注点，因为接受这些检查的患者通常有多种合并症。本文旨在探讨CIN的危险因素和临床过程，以及关于其预防和潜在治疗干预措施的最新研究，尤其是在经皮冠状动脉介入治疗期间。
