Saruya Kanako, Fukuda Hidetsugu, Saito Ryuzo, Urushibata Osamu, Mukai Hideki
Department of Dermatology, Toho University Ohashi Medical Center, Tokyo, Japan.
J Dermatol. 2009 Apr;36(4):232-6. doi: 10.1111/j.1346-8138.2009.00629.x.
Plasmocytosis circumorificialis is a benign chronic inflammatory disease, which causes erythema, erosions, ulcers, nodules and related changes in and around the openings of the human body, and is histopathologically characterized by dense infiltration of the dermis by plasma cells. We recently encountered a 49-year-old man in whom this disease affected the lower lip. On initial examination in our department, a well-demarcated region of erosion (10 mm x 5 mm), accompanied in part by formation of a crust, was noted on the left side of his lower lip. Histopathologically, the mucosal epithelium exhibited erosions, and dense plasma cell infiltration, without signs of atypia, was noted in the upper through middle layers of the lamina propria. On the basis of these findings, plasmocytosis circumorificialis was diagnosed. Because the patient had experienced repeated cycles of remission and relapse, despite topical treatment with various drugs (e.g. topical antibiotics and steroids), prior to referral to our department, we administered topical 2% fusidate sodium or Fucidin (Leo Pharmaceutical, Ballerup, Denmark) ointment. His eruption healed approximately 3 weeks after the start of this treatment. We report this case and discuss the findings reported in Japan on the development of plasmocytosis circumorificialis of the lips.
口周浆细胞增多症是一种良性慢性炎症性疾病，可导致人体开口处及其周围出现红斑、糜烂、溃疡、结节及相关变化，其组织病理学特征为真皮层有密集的浆细胞浸润。我们最近遇到一名49岁男性，该病累及了他的下唇。在我们科室初诊时，发现其下唇左侧有一个界限清楚的糜烂区域（10毫米×5毫米），部分伴有结痂形成。组织病理学检查显示，黏膜上皮出现糜烂，固有层上至中层可见密集的浆细胞浸润，未见异型性表现。基于这些发现，诊断为口周浆细胞增多症。由于该患者在转诊至我们科室之前，尽管使用了各种药物（如局部抗生素和类固醇）进行局部治疗，但病情仍反复缓解和复发，我们给予局部涂抹2%夫西地酸钠或肤西地酸（丹麦巴勒鲁普利奥制药公司生产）软膏。开始治疗约3周后，他的皮疹愈合。我们报告该病例，并讨论日本关于唇部口周浆细胞增多症发病情况的报道结果。
