Fujimura Taku, Furudate Sadanori, Ishibashi Masaya, Kambayashi Yumi, Tojo Gen-Ichi, Wakusawa Chihiro, Mayama Hiroshi, Aiba Setsuya
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Case Rep Dermatol. 2013 Mar 20;5(1):79-83. doi: 10.1159/000350184. Print 2013 Jan.
Plasmacytosis circumorificialis (PLC), a benign chronic inflammatory disease with an unknown pathogenesis, is characterized by erythema, erosion nodules and ulcers around the openings of the human body. In this report, we describe two cases of PLC successfully treated with topical tacrolimus. Interestingly, immunohistochemical staining revealed that prominent CD163(+) proinflammatory macrophages and IL-17-producing cells were infiltrating around plasma cells, which might suggest the reason for the therapeutic effect of topical tacrolimus on PLC.
口周浆细胞增多症（PLC）是一种发病机制不明的良性慢性炎症性疾病，其特征为人体开口周围出现红斑、糜烂性结节和溃疡。在本报告中，我们描述了两例经外用他克莫司成功治疗的PLC病例。有趣的是，免疫组化染色显示，在浆细胞周围有显著的CD163（+）促炎巨噬细胞和产生白细胞介素-17的细胞浸润，这可能提示了外用他克莫司对PLC治疗效果的原因。
