Iwayama-Hibino Michiko, Sugiura Kazumitsu, Muro Yoshinao, Tomita Yasushi
Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
J Dermatol. 2009 Apr;36(4):245-8. doi: 10.1111/j.1346-8138.2009.00632.x.
Topical hemotherapy is a method of applying heparinized venous blood directly onto the surface of an ulcer, which is covered with an occlusive hydrocolloidal dressing. It is often effective on chronic ulcers with thick necrosis, because some proteinases and growth factors in plasma are probably involved in the digestion of necrotic tissues and the acceleration of granulation and epithelization. We treated a patient with an intractable ulcer on the toe caused by a peripheral circulatory disturbance due to her systemic sclerosis. As conventional topical hemotherapy cannot be applied to ulcers on the round tip of a toe, we made a device for occlusive dressing of topical hemotherapy which could successfully improve the previously refractory ulcer.
局部血液疗法是一种将肝素化静脉血直接涂抹在溃疡表面的方法，溃疡表面覆盖有封闭性水胶体敷料。它对伴有严重坏死的慢性溃疡通常有效，因为血浆中的一些蛋白酶和生长因子可能参与坏死组织的消化以及肉芽形成和上皮形成的加速过程。我们治疗了一名因系统性硬化症导致外周循环障碍而在脚趾上出现顽固性溃疡的患者。由于传统的局部血液疗法无法应用于脚趾圆头处的溃疡，我们制作了一种用于局部血液疗法封闭敷料的装置，该装置成功改善了先前难以治愈的溃疡。
