Triquet B, Ruffieux P, Mainetti C, Salomon D, Saurat J H
Department of Dermatology, University Hospital, Geneva, Switzerland.
Dermatology. 1994;189(4):418-20. doi: 10.1159/000246897.
Several growth factors, present in the plasma or delivered by blood cells, are involved in wound healing. We have treated 15 chronic atonic leg ulcers by topical application of autologous heparinized blood under a hydrocolloidal dressing. This 'topical haemotherapy' (THT) was applied every other day. After the first THT, 30% of the fibrinonecrotic material had already been removed. After a mean of 9 THT applications (range: 5-18), granulation tissue covered up to 75% of the surface of the ulcer (range: 30-100%) allowing autologous skin grafting. No local or systemic side-effects occurred during the treatment. THT is feasible and well tolerated; it is an easy and inexpensive treatment of chronic leg ulcers that rapidly induces granulation tissue. Growth factors and proteases produced by the blood cells could play a relevant role in this process.
血浆中存在的或由血细胞传递的几种生长因子参与伤口愈合。我们通过在水胶体敷料下局部应用自体肝素化血液治疗了15例慢性弛缓性腿部溃疡。这种“局部血液疗法”（THT）每隔一天应用一次。首次THT后，30%的纤维蛋白坏死物质已被清除。平均进行9次THT应用（范围：5 - 18次）后，肉芽组织覆盖溃疡表面达75%（范围：30% - 100%），从而可以进行自体皮肤移植。治疗期间未出现局部或全身副作用。THT是可行的且耐受性良好；它是一种治疗慢性腿部溃疡的简便且廉价的方法，能迅速诱导肉芽组织形成。血细胞产生的生长因子和蛋白酶可能在此过程中发挥相关作用。
