Che Ronglin, Tang Wei, Zhang Jing, Wei Zhiyun, Zhang Zhao, Huang Ke, Zhao Xinzhi, Gao Jianjun, Zhou Guoquan, Huang Peirong, He Lin, Shi Yongyong
Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, PR China.
BMC Med Genet. 2009 Apr 6;10:31. doi: 10.1186/1471-2350-10-31.
2',3'-Cyclic nucleotide 3'-phosphodiesterase (CNP), one of the promising candidate genes for schizophrenia, plays a key part in the oligodendrocyte function and in myelination. The present study aims to investigate the relationship between CNP and schizophrenia in the Chinese population and the effect of different factors on the expression level of CNP in schizophrenia.
Five CNP single nucleotide polymorphisms (SNPs) were investigated in a Chinese Han schizophrenia case-control sample set (n = 180) using direct sequencing. The results were included in the following meta-analysis. Quantitative real-time polymerase chain reaction (PCR) was conducted to examine CNP expression levels in peripheral blood lymphocytes.
Factors including gender, genotype, sub-diagnosis and antipsychotics-treatment were found not to contribute to the expression regulation of the CNP gene in schizophrenia. Our meta-analysis produced similar negative results.
The results suggest that the CNP gene may not be involved in the etiology and pathology of schizophrenia in the Chinese population.
2',3'-环核苷酸3'-磷酸二酯酶（CNP）是精神分裂症颇具潜力的候选基因之一，在少突胶质细胞功能和髓鞘形成中起关键作用。本研究旨在探讨中国人群中CNP与精神分裂症的关系，以及不同因素对精神分裂症患者CNP表达水平的影响。
采用直接测序法，在中国汉族精神分裂症病例对照样本集（n = 180）中研究了5个CNP单核苷酸多态性（SNP）。研究结果纳入以下荟萃分析。采用定量实时聚合酶链反应（PCR）检测外周血淋巴细胞中CNP的表达水平。
发现性别、基因型、亚诊断和抗精神病药物治疗等因素对精神分裂症患者CNP基因的表达调控无影响。我们的荟萃分析也得出了类似的阴性结果。
结果表明，在中国人群中，CNP基因可能不参与精神分裂症的病因和病理过程。
