Baykan Merih, Erem Cihangir, Gedikli Omer, Hacihasanoglu Arif, Erdogan Turan, Kocak Mustafa, Kaplan Sahin, Korkmaz Levent, Celik Sükrü
Department of Cardiology, Division of Endocrinology, Karadeniz Technical University, Trabzon, Turkey.
Med Princ Pract. 2009;18(3):228-32. doi: 10.1159/000204355. Epub 2009 Apr 6.
The aim of this study was to assess flow-mediated dilatation (FMD) of the brachial artery in patients with acromegaly.
We prospectively evaluated 25 patients with acromegaly (14 females, 11 males; aged 42 +/- 12 years; growth hormone (GH) levels 34 +/- 14 ng/ml) and 27 control subjects (15 females, 12 males; aged 45 +/- 8 years; GH levels 3 +/- 1.5 ng/ml). The patients and controls were matched for age, gender, body mass index, cigarette smoking, blood pressure, lipid levels, diabetes mellitus, hypertension, and its duration. Endothelial function, measured as FMD of the brachial artery using ultrasound, was calculated in the 2 groups. The endothelial function was evaluated by assessing 1-min postischemic FMD of the brachial artery.
The FMD was lower in patients with acromegaly (9.97 +/- 3.5%) than in controls (16.1 +/- 3.4%), and the difference was statistically significant (p = 0.0001).
Endothelial dysfunction may develop in the preclinical phase of atherosclerosis in patients with acromegaly. Endothelium-dependent FMD may be impaired in acromegalic patients, and measurement of endothelial function may identify high-risk individuals earlier.
本研究旨在评估肢端肥大症患者肱动脉的血流介导的扩张（FMD）情况。
我们前瞻性地评估了25例肢端肥大症患者（14例女性，11例男性；年龄42±12岁；生长激素（GH）水平34±14 ng/ml）和27例对照者（15例女性，12例男性；年龄45±8岁；GH水平3±1.5 ng/ml）。患者和对照者在年龄、性别、体重指数、吸烟情况、血压、血脂水平、糖尿病、高血压及其病程方面进行了匹配。使用超声测量肱动脉的FMD来评估两组的内皮功能。通过评估肱动脉缺血后1分钟的FMD来评价内皮功能。
肢端肥大症患者的FMD（9.97±3.5%）低于对照者（16.1±3.4%），差异具有统计学意义（p = 0.0001）。
肢端肥大症患者在动脉粥样硬化临床前期可能出现内皮功能障碍。肢端肥大症患者的内皮依赖性FMD可能受损，内皮功能测量可更早识别高危个体。
