Hasin D S, Endicott J, Keller M B
Columbia University College of Physicians and Surgeons, School of Public Health, Division of Epidemiology, New York.
Compr Psychiatry. 1991 Jul-Aug;32(4):303-16. doi: 10.1016/0010-440x(91)90078-q.
Little is known about the occurrence and course of alcohol problems in patients with affective syndromes treated in psychiatric facilities. We have shown previously that a high proportion of such patients abused alcohol. In a 5-year follow-up of patients in the initial study, a large majority had a remission of their alcohol problems lasting at least 6 months, although many of these patients had subsequent relapses. Using survival analyses, we found that alcohol dependence indicators, previous chronicity of alcohol problems, and a diagnosis of schizoaffective disorder predicted poor outcome (specifically, longer time to remission of the alcohol problems). However, these factors were unrelated to receiving alcohol-specific treatment during the 5 years. Severity of social/occupational alcohol problems did not predict poor outcome, but did predict alcohol-specific treatment (detoxification, rehabilitation, Alcoholics Anonymous [AA], or Antabuse).
对于在精神科机构接受治疗的情感综合征患者中酒精问题的发生情况及病程,我们所知甚少。我们之前已经表明,这类患者中有很大比例滥用酒精。在初始研究中对患者进行的5年随访发现,尽管其中许多患者后来复发,但绝大多数患者的酒精问题缓解持续至少6个月。通过生存分析,我们发现酒精依赖指标、既往酒精问题的慢性程度以及精神分裂症情感障碍的诊断预示着预后不良(具体而言,酒精问题缓解所需时间更长)。然而,这些因素与5年期间接受酒精特异性治疗无关。社会/职业性酒精问题的严重程度并不能预示预后不良,但能预示酒精特异性治疗(戒酒、康复治疗、匿名戒酒会[AA]或戒酒硫)。