Hillion J, Mecucci C, Aventin A, Leroux D, Wlodarska I, Van Den Berghe H, Larsen C J
Unité 301-INSERM and SDI no. 15954 I CNRS, Institut de Génétique Moléculaire, Paris, France.
Oncogene. 1991 Jan;6(1):169-72.
We have examined three cases of human lymphoma bearing a t(2;18)(p11;q21) chromosome translocation. The bcl-2 gene appeared to be rearranged in all three cases and breakpoints were clustered in the 5' flanking region of the gene. In all three cases, bcl-2 was juxtaposed to J segments of the Ig kappa gene. This juxtaposition of the bcl-2 and Ig kappa genes is very similar to the variant chromosome translocations of Burkitt lymphoma that juxtapose the c-myc locus to IgL genes.
我们研究了3例携带t(2;18)(p11;q21)染色体易位的人类淋巴瘤病例。在所有3例病例中，bcl-2基因似乎都发生了重排，且断点聚集在该基因的5'侧翼区域。在所有3例病例中，bcl-2与Ig κ基因的J片段并列。bcl-2基因与Ig κ基因的这种并列与伯基特淋巴瘤的变异染色体易位非常相似，后者将c-myc基因座与IgL基因并列。
