Gao Yuan, Holland Ricky D, Yu Li-Rong
Division of Systems Toxicology, Center for Proteomics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
Brief Funct Genomic Proteomic. 2009 Mar;8(2):158-66. doi: 10.1093/bfgp/elp006. Epub 2009 Apr 7.
The emerging field of toxicoproteomics has been greatly advanced by quantitative proteomic technologies and their increasing applications in toxicology. The discipline is focused on the proteomic study of toxicity caused by toxic substances, including but not limited to drugs, toxins, environmental stressors, chemicals and any other materials that induce significant pathological responses. Drug safety is a major point of concern during the development phase and clinical application. Identification of toxicity biomarkers, potential drug targets and characterization of toxicity mechanisms represent major research areas for quantitative toxicoproteomics during drug development and evaluation. Further development and application of quantitative proteomic approaches would significantly facilitate the realization of personalized medicine.
定量蛋白质组学技术及其在毒理学中日益广泛的应用极大地推动了新兴的毒理蛋白质组学领域的发展。该学科专注于对有毒物质（包括但不限于药物、毒素、环境应激源、化学物质以及任何其他引发显著病理反应的物质）所导致的毒性进行蛋白质组学研究。药物安全性是药物研发阶段和临床应用过程中的一个主要关注点。在药物研发和评估过程中，毒性生物标志物的鉴定、潜在药物靶点的确定以及毒性机制的表征是定量毒理蛋白质组学的主要研究领域。定量蛋白质组学方法的进一步发展和应用将显著促进个性化医疗的实现。
