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对乙酰氨基酚诱导的急性肝损伤的转化生物标志物。

Translational biomarkers of acetaminophen-induced acute liver injury.

作者信息

Beger Richard D, Bhattacharyya Sudeepa, Yang Xi, Gill Pritmohinder S, Schnackenberg Laura K, Sun Jinchun, James Laura P

机构信息

Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, USA,

出版信息

Arch Toxicol. 2015 Sep;89(9):1497-522. doi: 10.1007/s00204-015-1519-4. Epub 2015 May 17.

DOI:10.1007/s00204-015-1519-4
PMID:25983262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4551536/
Abstract

Acetaminophen (APAP) is a commonly used analgesic drug that can cause liver injury, liver necrosis and liver failure. APAP-induced liver injury is associated with glutathione depletion, the formation of APAP protein adducts, the generation of reactive oxygen and nitrogen species and mitochondrial injury. The systems biology omics technologies (transcriptomics, proteomics and metabolomics) have been used to discover potential translational biomarkers of liver injury. The following review provides a summary of the systems biology discovery process, analytical validation of biomarkers and translation of omics biomarkers from the nonclinical to clinical setting in APAP-induced liver injury.

摘要

对乙酰氨基酚（APAP）是一种常用的镇痛药，可导致肝损伤、肝坏死和肝衰竭。APAP诱导的肝损伤与谷胱甘肽耗竭、APAP蛋白加合物的形成、活性氧和氮物种的产生以及线粒体损伤有关。系统生物学组学技术（转录组学、蛋白质组学和代谢组学）已被用于发现肝损伤的潜在转化生物标志物。以下综述总结了APAP诱导的肝损伤中系统生物学的发现过程、生物标志物的分析验证以及组学生物标志物从非临床到临床环境的转化。

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Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children.细胞外微小RNA作为儿童对乙酰氨基酚毒性生物标志物的潜力。
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Novel Optical Criteria and Mechanisms of Critical Decline in Liver Regenerative Potential.肝脏再生潜能临界下降的新型光学标准及机制
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