• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

复合体I缺乏与嗜酸细胞性甲状腺肿瘤相关。

Lack of complex I is associated with oncocytic thyroid tumours.

作者信息

Zimmermann F A, Mayr J A, Neureiter D, Feichtinger R, Alinger B, Jones N D, Eder W, Sperl W, Kofler B

机构信息

Department of Paediatrics, University Hospital Salzburg, Paracelsus Medical University, Muellner Hauptstrasse 48, A-5020 Salzburg, Austria.

出版信息

Br J Cancer. 2009 May 5;100(9):1434-7. doi: 10.1038/sj.bjc.6605028. Epub 2009 Apr 7.

DOI:10.1038/sj.bjc.6605028
PMID:19352385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2694433/
Abstract

Oncocytic tumours are characterised by hyperproliferation of mitochondria. We immunohistochemically analysed all enzymes of the oxidative phosphorylation system in 19 oncocytic thyroid tumours. A specific lack of complex I was detected, which was expressed at <5% of the level determined in surrounding non-cancerous tissue.

摘要

嗜酸性细胞瘤的特征是线粒体过度增殖。我们对19例甲状腺嗜酸性细胞瘤的氧化磷酸化系统的所有酶进行了免疫组化分析。检测到复合体I特异性缺乏，其表达水平低于周围非癌组织中所测水平的5%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94e6/2694433/a1612891e900/6605028f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94e6/2694433/bff5ac592fd8/6605028f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94e6/2694433/a1612891e900/6605028f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94e6/2694433/bff5ac592fd8/6605028f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94e6/2694433/a1612891e900/6605028f2.jpg

相似文献

1
Lack of complex I is associated with oncocytic thyroid tumours.复合体I缺乏与嗜酸细胞性甲状腺肿瘤相关。
Br J Cancer. 2009 May 5;100(9):1434-7. doi: 10.1038/sj.bjc.6605028. Epub 2009 Apr 7.
2
Immunohistochemical analysis of expression of nm23-H1/nucleoside diphosphate kinase in human thyroid carcinomas: lack of correlation between its expression and lymph node metastasis.人甲状腺癌中nm23-H1/核苷二磷酸激酶表达的免疫组织化学分析：其表达与淋巴结转移之间缺乏相关性。
Thyroid. 1993 Summer;3(2):105-9. doi: 10.1089/thy.1993.3.105.
3
Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III.甲状腺嗜酸细胞癌中氧化磷酸化缺陷与影响复合体I和复合体III的致病性线粒体DNA突变有关。
Cancer Res. 2006 Jun 15;66(12):6087-96. doi: 10.1158/0008-5472.CAN-06-0171.
4
The common deletion of mitochondrial DNA is found in goiters and thyroid tumors with and without oxyphil cell change.
Ultrastruct Pathol. 1998 May-Jun;22(3):271-3. doi: 10.3109/01913129809033479.
5
[Oncocytic tumors of the thyroid gland. Giant cell adenoma of the thyroid gland; Hürthle cell tumor].
Med Welt. 1970 Apr 11;15:668-71.
6
CD73 expression in normal, hyperplastic, and neoplastic thyroid: a systematic evaluation revealing CD73 overexpression as a feature of papillary carcinomas.CD73 在正常、增生和肿瘤性甲状腺中的表达：系统评价揭示 CD73 过表达是甲状腺乳头状癌的一个特征。
Virchows Arch. 2021 Jul;479(1):209-214. doi: 10.1007/s00428-021-03100-x. Epub 2021 May 21.
7
Function of HSP90 and p23 in the telomerase complex of thyroid tumors.HSP90和p23在甲状腺肿瘤端粒酶复合物中的作用。
Pathol Res Pract. 2003;199(9):573-9. doi: 10.1078/0344-0338-00464.
8
Expression of the embryonic morphogen Nodal in differentiated thyroid carcinomas: Immunohistochemistry assay in tissue microarray and The Cancer Genome Atlas data analysis.胚胎形态发生素Nodal在分化型甲状腺癌中的表达：组织芯片免疫组化检测及癌症基因组图谱数据分析
Surgery. 2014 Dec;156(6):1559-67; discussion 1567-8. doi: 10.1016/j.surg.2014.08.050. Epub 2014 Nov 11.
9
Decreased expression of thyrotropin receptor gene suggests a high-risk subgroup for oncocytic adenoma.促甲状腺激素受体基因表达降低提示嗜酸细胞腺瘤的一个高危亚组。
Eur J Endocrinol. 2004 Mar;150(3):269-76. doi: 10.1530/eje.0.1500269.
10
Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors.复合体 I 亚基中的线粒体 DNA 破坏性突变是甲状腺肿瘤嗜酸细胞表型的标志物。
Proc Natl Acad Sci U S A. 2007 May 22;104(21):9001-6. doi: 10.1073/pnas.0703056104. Epub 2007 May 15.

引用本文的文献

1
Mitochondrial Oxidative Phosphorylation Alterations in Placental Tissues from Early- and Late-Onset Preeclampsia.早发型和晚发型子痫前期胎盘组织中线粒体氧化磷酸化的改变
Int J Mol Sci. 2025 Apr 22;26(9):3951. doi: 10.3390/ijms26093951.
2
The Interplay between Dysregulated Metabolism and Epigenetics in Cancer.代谢失调与癌症表观遗传学的相互作用
Biomolecules. 2023 Jun 5;13(6):944. doi: 10.3390/biom13060944.
3
Hydrogen Sulfide Metabolizing Enzymes in the Intestinal Mucosa in Pediatric and Adult Inflammatory Bowel Disease.小儿及成人炎症性肠病肠道黏膜中的硫化氢代谢酶

本文引用的文献

1
Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death.颗粒酶A切割线粒体复合物I蛋白以启动不依赖半胱天冬酶的细胞死亡。
Cell. 2008 May 16;133(4):681-92. doi: 10.1016/j.cell.2008.03.032.
2
Loss of complex I due to mitochondrial DNA mutations in renal oncocytoma.肾嗜酸细胞瘤中线粒体DNA突变导致复合体I缺失。
Clin Cancer Res. 2008 Apr 15;14(8):2270-5. doi: 10.1158/1078-0432.CCR-07-4131.
3
ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.产生活性氧的线粒体DNA突变可调节肿瘤细胞转移。
Antioxidants (Basel). 2022 Nov 12;11(11):2235. doi: 10.3390/antiox11112235.
4
Oncocytic lesions of the ocular adnexa: A review of the histopathology with a brief discussion of the pathogenesis.眼附属器的嗜酸性细胞病变：组织病理学综述及发病机制简要讨论
Saudi J Ophthalmol. 2022 Apr 18;35(3):179-185. doi: 10.4103/SJOPT.SJOPT_93_21. eCollection 2021 Jul-Sep.
5
The Entanglement between Mitochondrial DNA and Tumor Metastasis.线粒体DNA与肿瘤转移之间的关联
Cancers (Basel). 2022 Apr 7;14(8):1862. doi: 10.3390/cancers14081862.
6
Expression of Oxidative Phosphorylation Complexes and Mitochondrial Mass in Pediatric and Adult Inflammatory Bowel Disease.氧化磷酸化复合物和线粒体质量在儿科和成人炎症性肠病中的表达。
Oxid Med Cell Longev. 2022 Jan 6;2022:9151169. doi: 10.1155/2022/9151169. eCollection 2022.
7
Platelet Mitochondrial Bioenergetics Reprogramming in Patients with Urothelial Carcinoma.血小板线粒体生物能在膀胱癌患者中的重编程。
Int J Mol Sci. 2021 Dec 30;23(1):388. doi: 10.3390/ijms23010388.
8
Papillary thyroid carcinoma tall cell variant shares accumulation of mitochondria, mitochondrial DNA mutations, and loss of oxidative phosphorylation complex I integrity with oncocytic tumors.甲状腺乳头状癌高细胞型变体与嗜酸细胞瘤一样，存在线粒体积累、线粒体 DNA 突变和氧化磷酸化复合物 I 完整性丧失。
J Pathol Clin Res. 2022 Mar;8(2):155-168. doi: 10.1002/cjp2.247. Epub 2021 Nov 17.
9
Inherited Thyroid Tumors With Oncocytic Change.具有嗜酸细胞改变的遗传性甲状腺肿瘤。
Front Endocrinol (Lausanne). 2021 Jun 9;12:691979. doi: 10.3389/fendo.2021.691979. eCollection 2021.
10
Mitochondria in cancer.癌症中的线粒体
Cell Stress. 2020 May 11;4(6):114-146. doi: 10.15698/cst2020.06.221.
Science. 2008 May 2;320(5876):661-4. doi: 10.1126/science.1156906. Epub 2008 Apr 3.
4
Clonal expansion of mutated mitochondrial DNA is associated with tumor formation and complex I deficiency in the benign renal oncocytoma.突变型线粒体DNA的克隆性扩增与良性肾嗜酸细胞瘤的肿瘤形成及复合体I缺陷相关。
Hum Mol Genet. 2008 Apr 1;17(7):986-95. doi: 10.1093/hmg/ddm371. Epub 2007 Dec 21.
5
Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors.复合体 I 亚基中的线粒体 DNA 破坏性突变是甲状腺肿瘤嗜酸细胞表型的标志物。
Proc Natl Acad Sci U S A. 2007 May 22;104(21):9001-6. doi: 10.1073/pnas.0703056104. Epub 2007 May 15.
6
Oncocytic meningiomas: Cases with benign histopathological features and a favorable clinical course.嗜酸性细胞型脑膜瘤：具有良性组织病理学特征及良好临床病程的病例
J Neurosurg. 2006 Nov;105(5):736-8. doi: 10.3171/jns.2006.105.5.736.
7
Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III.甲状腺嗜酸细胞癌中氧化磷酸化缺陷与影响复合体I和复合体III的致病性线粒体DNA突变有关。
Cancer Res. 2006 Jun 15;66(12):6087-96. doi: 10.1158/0008-5472.CAN-06-0171.
8
Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid.GRIM-19是一种参与线粒体代谢和细胞死亡的双功能基因，其体细胞和生殖系突变与富含线粒体的（许特耳细胞）甲状腺肿瘤有关。
Br J Cancer. 2005 May 23;92(10):1892-8. doi: 10.1038/sj.bjc.6602547.
9
Human mitochondrial complex I assembles through the combination of evolutionary conserved modules: a framework to interpret complex I deficiencies.人类线粒体复合体I通过进化保守模块的组合进行组装：一种解释复合体I缺陷的框架。
Hum Mol Genet. 2004 Oct 15;13(20):2461-72. doi: 10.1093/hmg/ddh262. Epub 2004 Aug 18.
10
Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain.细胞凋亡过程中线粒体功能的破坏是由电子传递链复合体I的p75亚基的半胱天冬酶切割介导的。
Cell. 2004 Jun 11;117(6):773-86. doi: 10.1016/j.cell.2004.05.008.