Lack of complex I is associated with oncocytic thyroid tumours.
作者信息
Zimmermann F A, Mayr J A, Neureiter D, Feichtinger R, Alinger B, Jones N D, Eder W, Sperl W, Kofler B
机构信息
Department of Paediatrics, University Hospital Salzburg, Paracelsus Medical University, Muellner Hauptstrasse 48, A-5020 Salzburg, Austria.
出版信息
Br J Cancer. 2009 May 5;100(9):1434-7. doi: 10.1038/sj.bjc.6605028. Epub 2009 Apr 7.
Abstract
Oncocytic tumours are characterised by hyperproliferation of mitochondria. We immunohistochemically analysed all enzymes of the oxidative phosphorylation system in 19 oncocytic thyroid tumours. A specific lack of complex I was detected, which was expressed at <5% of the level determined in surrounding non-cancerous tissue.
摘要
Zotero 插件