微阵列技术在急性髓细胞白血病中的应用。
Applications of microarray technology to Acute Myelogenous Leukemia.
作者信息
Goswami Rashmi S, Sukhai Mahadeo A, Thomas Mariam, Reis Patricia P, Kamel-Reid Suzanne
机构信息
Division of Applied Molecular Oncology, Princess Margaret Hospital/Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.
出版信息
Cancer Inform. 2009;7:13-28. doi: 10.4137/cin.s1015. Epub 2008 Dec 22.
Microarray technology is a powerful tool, which has been applied to further the understanding of gene expression changes in disease. Array technology has been applied to the diagnosis and prognosis of Acute Myelogenous Leukemia (AML). Arrays have also been used extensively in elucidating the mechanism of and predicting therapeutic response in AML, as well as to further define the mechanism of AML pathogenesis. In this review, we discuss the major paradigms of gene expression array analysis, and provide insights into the use of software tools to annotate the array dataset and elucidate deregulated pathways and gene interaction networks. We present the application of gene expression array technology to questions in acute myelogenous leukemia; specifically, disease diagnosis, treatment and prognosis, and disease pathogenesis. Finally, we discuss several new and emerging array technologies, and how they can be further utilized to improve our understanding of AML.
微阵列技术是一种强大的工具，已被应用于增进对疾病中基因表达变化的理解。阵列技术已应用于急性髓性白血病（AML）的诊断和预后评估。阵列在阐明AML的发病机制、预测治疗反应以及进一步明确AML发病机制方面也得到了广泛应用。在本综述中，我们讨论了基因表达阵列分析的主要模式，并深入探讨了使用软件工具注释阵列数据集以及阐明失调途径和基因相互作用网络的方法。我们介绍了基因表达阵列技术在急性髓性白血病相关问题中的应用；具体而言，包括疾病诊断、治疗和预后以及疾病发病机制。最后，我们讨论了几种新出现的阵列技术，以及如何进一步利用它们来加深我们对AML的理解。
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