Nikiforova Marina N, Chiosea Simon I, Nikiforov Yuri E
Department of Pathology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
Endocr Pathol. 2009 Summer;20(2):85-91. doi: 10.1007/s12022-009-9069-z.
MicroRNAs (miRNAs) constitute a recently identified class of small endogenous noncoding RNAs that act as negative regulators of the protein-coding gene expression and may impact cell differentiation, proliferation and survival, i.e., all fundamental cellular processes implicated in carcinogenesis. miRNA expression is deregulated in many types of human cancers, including thyroid cancer. The purpose of this review is to summarize the existing findings of miRNA deregulation in thyroid tumors and its potential role in thyroid cancer biology and molecular diagnostics.
微小RNA（miRNA）是最近发现的一类内源性小非编码RNA，它们作为蛋白质编码基因表达的负调节因子，可能影响细胞分化、增殖和存活，即参与致癌作用的所有基本细胞过程。miRNA表达在包括甲状腺癌在内的多种人类癌症中失调。本综述的目的是总结甲状腺肿瘤中miRNA失调的现有发现及其在甲状腺癌生物学和分子诊断中的潜在作用。
